Protein-losing Enteropathy Associated With Refractory Systemic Lupus Erythematosus With a Good Response to Rituximab
| Autor: | Mercedes A. García, Pierina Sansinanea, Josefina Marcos, Sebastián Augusto Carrica |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adolescent
Anti-nuclear antibody Protein-Losing Enteropathies 03 medical and health sciences 0302 clinical medicine Recurrence immune system diseases hemic and lymphatic diseases medicine Humans Lupus Erythematosus Systemic Enteropathy Hypoalbuminemia skin and connective tissue diseases 030203 arthritis & rheumatology Lupus anticoagulant business.industry Protein losing enteropathy General Medicine medicine.disease Immunology Female 030211 gastroenterology & hepatology Rituximab medicine.symptom Malar rash business Immunosuppressive Agents medicine.drug Anti-SSA/Ro autoantibodies |
| Zdroj: | Reumatología Clínica (English Edition). 12:47-49 |
| ISSN: | 2173-5743 |
| DOI: | 10.1016/j.reumae.2015.01.010 |
| Popis: | A case is presented of a protein-losing enteropathy (PLE) as the initial manifestation of systemic lupus erythematosus (SLE) in a 17 year-old female patient, who presented with ascites, edema and hypoalbuminemia. The diagnosis of SLE was based on the presence of: malar rash, oral ulcers, thrombocytopenia, antinuclear antibodies, IgM anticardiolipin antibody, and lupus anticoagulant. Renal and liver diseases were ruled out. The PLE diagnosis was confirmed with fecal alpha 1-antitrypsin clearance. The PLE was refractory to different lines of immunosuppressive agents like glucocorticoids, cyclophosphamide, azathioprine, and cyclosporine, showing a satisfactory and sustained response with rituximab, allowing steroid sparing and long term remission. |
| Databáze: | OpenAIRE |
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