Replete vitamin D stores predict reproductive success following in vitro fertilization
| Autor: | Gohar Zeitlian, Jun Shu, Cheryl Hickmon, Sebiha Özkan, Keri Greenseid, Sangita Jindal, Lubna Pal |
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| Rok vydání: | 2008 |
| Předmět: |
Vitamin
Adult medicine.medical_specialty Pregnancy Rate Fertilization in Vitro Article Andrology Cohort Studies chemistry.chemical_compound Predictive Value of Tests Pregnancy medicine Vitamin D and neurology Humans Embryo Implantation Vitamin D Prospective cohort study Gynecology business.industry Reproduction Obstetrics and Gynecology medicine.disease Follicular fluid Embryo transfer Follicular Fluid Pregnancy rate Treatment Outcome Reproductive Medicine chemistry Female business Body mass index Infertility Female |
| Zdroj: | Fertility and sterility. 94(4) |
| ISSN: | 1556-5653 |
| Popis: | Objective To determine whether 25OH-D levels in the follicular fluid (FF) of infertile women undergoing IVF demonstrate a relationship with IVF cycle parameters and outcome, hypothesizing that levels of 25OH-D in body fluids are reflective of vitamin repletion status. Design Prospective cohort study. Setting Academic tertiary care center. Patient(s) Eighty-four infertile women undergoing IVF. Intervention(s) Follicular fluid from follicles ≥14mm; serum (n = 10) and FF levels of 25OH-D. Main Outcome Measure(s) Clinical pregnancy (CP), defined as evidence of intrauterine gestation sac on ultrasound, following IVF; IVF cycle parameters. Result(s) Serum and FF levels of 25OH-D were highly correlated (r = 0.94). In a predominantly Caucasian population (66%), significantly lower FF 25OH-D levels were noted in Black versus non-Black patients. Significant inverse correlations were seen between FF 25OH-D levels and body mass index (r = –0.25). Significantly higher CP and implantation rates were observed across tertiles of FF25OH-D; patients achieving CP following IVF (n = 26) exhibited significantly higher FF levels of 25OH-D. Multivariable logistic regression analysis confirmed FF 25OH-D levels as an independent predictor to success of an IVF cycle; adjusting for age, body mass index, ethnicity, and number of embryos transferred, each ng/mL increase in FF 25OH-D increased the likelihood for achieving CP by 6%. Conclusion(s) Our findings that women with higher vitamin D level in their serum and FF are significantly more likely to achieve CP following IVF–embryo transfer are novel. A potential for benefit of vitamin D supplementation on treatment success in infertile patients undergoing IVF is suggested and merits further investigation. |
| Databáze: | OpenAIRE |
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