Telomerase activity and telomere length of peripheral blood mononuclear cells in SLE patients
| Autor: | Daitaro Kurosaka, Yoshinori Ozawa, Toru Yokoyama, Yutaka Obayashi, Ken Yoshida, Jun Yasuda, Isamu Kingetsu, Saburo Saito, Akio Yamada |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Telomerase Adolescent Prednisolone Remission Spontaneous Statistics as Topic Anti-Inflammatory Agents 030204 cardiovascular system & hematology Peripheral blood mononuclear cell Statistics Nonparametric Hemoglobins 03 medical and health sciences 0302 clinical medicine Rheumatology Older patients immune system diseases Sickness Impact Profile Humans Lupus Erythematosus Systemic Medicine Clinical significance In patient skin and connective tissue diseases Aged 030203 arthritis & rheumatology Lupus erythematosus Dose-Response Relationship Drug business.industry Age Factors Middle Aged Telomere medicine.disease Dose–response relationship Treatment Outcome Immunology Leukocytes Mononuclear Female business Biomarkers Follow-Up Studies |
| Zdroj: | Lupus. 12:591-599 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1191/0961203303lu426oa |
| Popis: | We evaluated the clinical significance of the telomerase activity and telomere length of peripheral blood mononuclearcells (PBMC) in systemic lupus erythematosus (SLE). PBMC were isolated from 55 patients with SLE and the telomerase activity was measured by TRAP assay. The telomere length of PBMC was also measured in 30 of these subjects. As a control group, 45 healthy adults with no particular clinical history were studied. The results were compared with clinical data. In patients with active SLE, the telomerase activity of PBMC was significantly increased compared with the control group. In patients with inactive SLE, the PBMC telomerase activity was not different compared with the controls in their 20s, 30s and 40s, but it was significantly increased compared with the controls in their 50s. In SLE patients, the telomerase activity of PBMC was significantly correlatedwith modified SLEDAI. The telomere length of PBMC in younger SLE patients tended to be shorter than that in the controls, but no difference was observed in older patients. The correlation coefficient between the telomerase activity and telomere length of PBMC in SLE patients was not significant. Abnormalities in the telomeraseactivity and telomere length observedin SLE patients are consideredto be important findings for evaluation of the pathology of SLE. |
| Databáze: | OpenAIRE |
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