Intraoperative periarticular injection can alleviate the inflammatory response and enhance joint function recovery after hip arthroplasty in elderly patients with osteoporotic femoral neck fractures
| Autor: | Liu Fang, Lingling Zhou, Xiong Zhizheng, Hu Jinxi, Yongwei Li, Liu Qi, Shuai Cao, Xu Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Epinephrine Visual analogue scale medicine.medical_treatment Arthroplasty Replacement Hip Placebo Femoral Neck Fractures Betamethasone periarticular injection law.invention Injections Intra-Articular 03 medical and health sciences 0302 clinical medicine Postoperative Complications Randomized controlled trial law medicine Humans Ropivacaine 030212 general & internal medicine osteoporotic femoral neck fractures Aged Intraoperative Care medicine.diagnostic_test Morphine business.industry General Medicine Venous blood Clinical Trial/Experimental Study inflammatory response Isoxazoles Recovery of Function Arthroplasty Surgery Harris Hip Score 030220 oncology & carcinogenesis Erythrocyte sedimentation rate Drug Therapy Combination Female Inflammation Mediators business hip joint function Biomarkers Osteoporotic Fractures Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Purpose: This study aimed to investigate the potential beneficial effects of periarticular injection (PAI) of multimodal drugs on the inflammatory response and joint function after hip arthroplasty in elderly patients with osteoporotic femoral neck fractures. Methods: Fifty six elderly patients with unilateral osteoporotic femoral neck fractures were randomly allocated to 2 groups: the PAI group, which received the multimodal drug PAI intraoperatively before incision closure, and the control group, which received an injection of saline at the same time as placebo. The C-reactive protein (CRP), interleukin-1β (IL-1β), and IL-6 levels as well as the erythrocyte sedimentation rate (ESR) in peripheral venous blood samples were measured, along with the Visual Analogue Scale (VAS) score with activity and Harris hip score preoperation at 1, 2, 4, 7, and 14 days as well as 1 and 3 months post-operation. Results: The 2 groups were comparable in sex and age, and no significant differences were observed in the preoperative CRP, IL-1β, and IL-6 levels, ESR, VAS score, or Harris hip score between the 2 groups (all P > .05). However, during the postoperative period, the PAI group exhibited significantly lower levels of CRP, IL-1β, and IL-6 as well as a lower ERS and VAS score compared with the control group (P |
| Databáze: | OpenAIRE |
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