Influence of von Willebrand factor on common pathophysiological mechanisms of cerebrovascular diseases and multiple sclerosis
| Autor: | Ivan Koltsov, M Yu Martynov, A N Boyko, M. S. Fidler, A N Yasamanova, I A Shchukin |
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| Rok vydání: | 2021 |
| Předmět: |
biology
Mechanism (biology) Angiogenesis business.industry Multiple sclerosis Context (language use) multiple sclerosis medicine.disease stroke endothelial dysfunction von willebrand factor Proinflammatory cytokine Psychiatry and Mental health Clinical Psychology Von Willebrand factor Coagulation Immunology medicine biology.protein Neurology. Diseases of the nervous system Neurology (clinical) Endothelial dysfunction RC346-429 business cerebrovascular diseases |
| Zdroj: | Nevrologiâ, Nejropsihiatriâ, Psihosomatika, Vol 13, Iss 1S, Pp 62-68 (2021) |
| ISSN: | 2310-1342 2074-2711 |
| Popis: | Endothelial dysfunction is a universal pathological mechanism underlying or contributing to the development/progression of many diseases, including cerebrovascular disease and multiple sclerosis. Von Willebrand factor is a multimeric glycoprotein synthesized by endothelial cells and megakaryocytes that participates in a range of physiological and pathological processes, including primary hemostasis and coagulation. It also regulates secretion and transport of a variety of molecules, exerts a proinflammatory effect, modulates angiogenesis and smooth muscle mitotic activity, influences atherogenesis. In this review, we discuss the synthesis, secretion, and regulation of the von Willebrand factor within the context of endothelial dysfunction and other common mechanisms that play a significant role in brain tissue damage in cerebrovascular diseases and multiple sclerosis. |
| Databáze: | OpenAIRE |
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