Promoting effect of biliverdin for liver cells initiated by aflatoxin B1
| Autor: | C. Frayssinet, G. Trincal, C. Lafarge-Frayssinet, E. Morel-Chany |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Cancer Research
Aflatoxin Aflatoxin B1 medicine.disease_cause chemistry.chemical_compound Pigment Aflatoxins polycyclic compounds medicine Animals Neoplastic transformation Cells Cultured Biliverdin Cocarcinogenesis Contact Inhibition Low dose Biliverdine Bilirubin Rats Inbred Strains Hemoglobin catabolism Rats Cell Transformation Neoplastic Oncology chemistry Biochemistry Liver visual_art Hepatic stellate cell visual_art.visual_art_medium Carcinogens Carcinogenesis |
| Zdroj: | Cancer letters. 18(3) |
| ISSN: | 0304-3835 |
| Popis: | In this paper we have studied the participation of biliverdin, a bile pigment produced from hemoglobin catabolism, in a two-stage carcinogenesis model using hepatic cells in culture. The initiation was realised by a short term exposure to low doses of aflatoxin B1. The cells were then cultivated in the presence of biliverdin in the medium. We observed that biliverdin increased the rate and the efficiency of neoplastic transformation of cells. These results suggest that biliverdin may act as a promoting substance. |
| Databáze: | OpenAIRE |
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