Post-coital administration of levonorgestrel does not interfere with post-fertilization events in the new-world monkey Cebus apella
| Autor: | R. E. Ortiz, Horacio B. Croxatto, M. E. Ortiz, M. A. Fuentes, V. H. Parraguez |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Ovulation endocrine system medicine.medical_specialty Time Factors Pregnancy Rate media_common.quotation_subject medicine.medical_treatment Physiology Levonorgestrel Biology Human fertilization Ovarian Follicle Pregnancy Internal medicine medicine Animals Cebus Emergency contraception Ovarian follicle media_common Ultrasonography Contraceptives Postcoital Synthetic Rehabilitation Ovary Obstetrics and Gynecology Mifepristone medicine.disease Pregnancy rate medicine.anatomical_structure Endocrinology Fertility Reproductive Medicine Follicular Phase Female medicine.drug |
| Zdroj: | Human reproduction (Oxford, England). 19(6) |
| ISSN: | 0268-1161 |
| Popis: | BACKGROUND: Experimental evidence to disprove the belief that emergency contraception with levonorgestrel (LNG) prevents pregnancy by interfering with post-fertilization events is lacking. Here we determined the effect of post-coital and pre-ovulatory administration of LNG on fertility and ovulation, respectively, in the Cebus monkey. METHODS: To determine the effect on fertility, LNG 0.75 mg or vehicle were administered orally or s.c. once or twice within the first 24 h after mating occurring very close to the time of ovulation. Females that became pregnant were aborted with mifepristone and re-entered the study after a resting cycle until each of 12 females had contributed, in a randomized order, two LNG and two vehicle-treated cycles. To determine the effect on ovulation, LNG 0.75 mg or vehicle were injected twice coinciding with follicles smaller or larger than 5 mm in diameter. Six females contributed five treated cycles each. RESULTS: The pregnancy rate was identical in vehicle- and LNG-treated cycles. LNG inhibited or delayed ovulation only when treatment coincided with a follicle |
| Databáze: | OpenAIRE |
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