Incidence and characteristics of nosocomial influenza in a country with low vaccine coverage
| Autor: | Stéphane Jouneau, C. Grolhier, D. Luque-Paz, B. Bayeh, A. Le Bot, Charlotte Pronier, Pierre Tattevin, Vincent Thibault, François Bénézit |
|---|---|
| Přispěvatelé: | Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Laboratoire de Virologie [Rennes] = Virology [Rennes], Service de pneumologie [Rennes] = Pneumology [Rennes], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Microbiology (medical) Pediatrics medicine.medical_specialty Vaccination Coverage Adolescent Health Personnel [SDV]Life Sciences [q-bio] Influenza season 030501 epidemiology Virus Young Adult 03 medical and health sciences Elderly Interquartile range Influenza Human medicine Humans Child Aged Retrospective Studies Outcome Aged 80 and over Cross Infection 0303 health sciences 030306 microbiology Transmission (medicine) business.industry Incidence (epidemiology) Incidence Polymerase chain reaction analysis virus diseases General Medicine Middle Aged 3. Good health Hospitalization Influenza B virus Infectious Diseases Influenza Vaccines Nosocomial influenza Child Preschool Vaccination coverage Female France 0305 other medical science business Vaccine |
| Zdroj: | Journal of Hospital Infection Journal of Hospital Infection, WB Saunders, 2020, 105, pp.619-624. ⟨10.1016/j.jhin.2020.06.005⟩ Journal of Hospital Infection, 2020, 105 (4), pp.619-624. ⟨10.1016/j.jhin.2020.06.005⟩ |
| ISSN: | 0195-6701 1532-2939 |
| DOI: | 10.1016/j.jhin.2020.06.005⟩ |
| Popis: | Influenza vaccination coverage is low in France, in at-risk patients and in healthcare workers.We aimed to estimate the incidence of nosocomial influenza, its characteristics and outcome.During one influenza season, we retrospectively evaluated all cases of documented influenza. Inpatients with symptoms onset ≥48 h after admission were enrolled. Data were collected on a standardized questionnaire.From November 2017 to April 2018, 860 patients tested positive for influenza by polymerase chain reaction analysis on a respiratory sample. Among them, 204 (23.7%) were diagnosed ≥48 h after admission, of whom 57 (6.6% of all influenza cases) fulfilled inclusion criteria for nosocomial influenza: 26 women and 31 men, median age 82 years (interquartile range, 72.2-86.9). Twenty patients (38.6%) had recently (6 months) received the seasonal influenza vaccine. Median time between admission and symptoms onset, and between symptoms onset and diagnosis were, respectively, 11 days (7-19.5) and 29 h (15.5-48). Influenza was mostly acquired in a double-bedded room (N = 39, 68.4%), with documented exposure in 14 cases. Influenza B virus was more common in nosocomial (46/57, 80.7%), than in community-acquired cases (359/803, 44.6%), P0.001. Mortality rate at three months was 15.8% (N = 9). Incidence of nosocomial influenza was estimated at 0.22 per 1000 hospital-days during the study period.Nosocomial influenza is not rare in elderly inpatients, and may have severe consequences. Influenza B virus was over-represented, which suggests higher transmissibility and/or transmission clusters. |
| Databáze: | OpenAIRE |
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