Antidiabetic effect of the scorpionScorpio maurus palmatusbody extract using alloxan-induced diabetic mice model
| Autor: | Sherifa H. Ahmed, Mohamed A. Abdel-Rahman, Yaser S. Binnaser, Ismail M. Abdel-Nabi, Ahmad K. Mohammed |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Scorpion 02 engineering and technology medicine.disease_cause complex mixtures 01 natural sciences 010305 fluids & plasmas chemistry.chemical_compound Internal medicine Diabetes mellitus biology.animal Alloxan 0103 physical sciences medicine oxidative stress pancreas lcsh:Science (General) Mode of action biology business.industry Scorpio maurus palmatus Diabetic mouse 021001 nanoscience & nanotechnology medicine.disease scorpion extract antioxidants Endocrinology chemistry diabetes mellitus histopathology Histopathology 0210 nano-technology business Oxidative stress lcsh:Q1-390 |
| Zdroj: | Journal of Taibah University for Science, Vol 13, Iss 1, Pp 504-513 (2019) |
| ISSN: | 1658-3655 |
| DOI: | 10.1080/16583655.2019.1599184 |
| Popis: | The antidiabetic effect and mode of action of Socrpio maurus palmatus body extract were evaluated in diabetic mice induced by alloxan. 24 male albino mice were divided into four groups. Group 1 was injected intraperitoneally with physiological saline. Group 2 was injected (i.p., daily for 5 weeks) with 300 mg/kg of the scorpion aqueous extract. Group 3 was received alloxan (150 mg/kg, i.p). Group 4 was diabetic and treated with scorpion extract (300 mg/kg, i.p., daily for 5 weeks). Several relevant biochemical parameters and histological examination of Langerhans islets were evaluated. The administration of scorpion extract significantly elevated the level of plasma insulin which was concomitant with a remarkable decrease in the level of blood glucose in diabetic mice. Furthermore, scorpion extract showed a notable ameliorative effect through enhancing the status of antioxidants and recovering the altered biochemical parameters in diabetic mice. Interestingly, scorpion extract significantly increased the number of β-cells and the size of pancreatic islets in diabetic mice. Accordingly, the obtained results demonstrate the antidiabetic effect of scorpion extract in alloxan-induced diabetic mice through its antioxidant and regeneration capacity. |
| Databáze: | OpenAIRE |
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