Outcomes in N3 Head and Neck Squamous Cell Carcinoma and Role of Upfront Neck Dissection
| Autor: | Haitham Mirghani, Yungan Tao, A. Boros, Caroline Even, François Bidault, Philippe Gorphe, Eric Deutsch, Stéphane Temam, Pierre Blanchard, François Janot, Arlette Dade, Ingrid Breuskin |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Male medicine.medical_specialty Multivariate analysis medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Concurrent chemotherapy Internal medicine Medicine Humans Aged Retrospective Studies business.industry Squamous Cell Carcinoma of Head and Neck Head and neck cancer Cancer Neck dissection Chemoradiotherapy Middle Aged medicine.disease Head and neck squamous-cell carcinoma Radiation therapy Survival Rate 030104 developmental biology Treatment Outcome Otorhinolaryngology Head and Neck Neoplasms 030220 oncology & carcinogenesis Neck Dissection Female Neoplasm Grading business |
| Zdroj: | The LaryngoscopeBIBLIOGRAPHY. 131(3) |
| ISSN: | 1531-4995 |
| Popis: | We investigated the prognostic factor of N3 head and neck squamous cell carcinoma (HNSCC), including the role of upfront neck dissection (UFND) before radiotherapy (RT).We retrospectively reviewed the charts of consecutive N3 HNSCC patients treated with curative intent RT.In the study, 323 N3 HNSCC patients were included. Of those, 125 patients (39%) had UFND. Median follow-up was 3.9 years (0-14.8 years). Overall survival (OS) at 5 years was 31.2%, and progression-free survival (PFS) was 26%. In the multivariate analysis, OS was improved in PS 0, T1-2 tumors, patients receiving concurrent chemotherapy, never or former smokers, and UFND. UFND was strongly associated with increased OS (45.7% vs. 21.2%, P .001), and PFS (P .001). Regardless of neck node size, UFND improved survival (P = .001 for ≤ 7 cm and P = .004 for 7 cm).UFND could improve treatment outcomes in N3 HNSCC, especially for non-oropharyngeal cancer, regardless of neck node size.2B Laryngoscope, 131:E844-E850, 2021. |
| Databáze: | OpenAIRE |
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