Assessment of Cytokines, Biochemical Markers of Malnutrition and Frailty Syndrome Patients Considered for Lung Transplantation
| Autor: | Marian Zembala, Anna Łaszewska, Marek Ochman, Anita Stanjek-Cichoracka, Elżbieta Woźniak-Grygiel |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Lung Diseases Male medicine.medical_specialty Canada medicine.medical_treatment Frailty syndrome Enzyme-Linked Immunosorbent Assay Gastroenterology Proinflammatory cytokine Contraindications Procedure Pulmonary Disease Chronic Obstructive Young Adult Internal medicine medicine Lung transplantation Humans Lung Triglycerides Transplantation Bronchiectasis Frailty business.industry Patient Selection Cholesterol HDL Malnutrition Middle Aged medicine.disease Interleukin-10 Cytokine medicine.anatomical_structure C-Reactive Protein Population study Cytokines Surgery Interleukin 18 Female business Biomarkers Lung Transplantation |
| Zdroj: | Transplantation proceedings. 51(6) |
| ISSN: | 1873-2623 |
| Popis: | Background The aim of the study was to investigate the serum concentration of cytokines and biochemical markers of malnutrition in correlation with frailty syndrome in patients qualified for lung transplantation (LTx). Methods The study population comprised 31 potential lung recipients, including 18 patients with idiopathic lung disease, 12 patients with chronic obstructive pulmonary disease, and 1 patient with bronchiectasis who qualified for a LTx. Cytokine serum levels were assessed using commercially available enzyme-linked immunosorbent assay kits and the Luminex 200 platform (ProcartaPlex Hu Cytokine/Chemokine Panel 1A 34plex, Invitrogen, Carlsbad, Calif., United States). The patients were also asked to complete a questionnaire, the Clinical Frailty Scale. Results All patients were found to have higher cytokine concentrations (IL6, IL 2,IL18, IL23, IL 12p70, IL 10, IL 7). No statistically significant differences in the analyzed cytokines were noted when the men's results were compared to those of the women. There were no significant differences between patients who scored 6 vs 7 points on the Canadian Study of Health and Aging Function Scale. In comparing chronic obstructive pulmonary disease to idiopathic lung disease patients, no significant differences were observed in the analyzed cytokine values. Significant correlations were observed between the analyzed cytokines and age of the patients, C-reactive protein, triglycerides, transferrin, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. Conclusions Our findings indicate that cytokines may not have a statistically significant effect on the parameters of the frailty syndrome. The results require further investigations on larger study groups. The findings suggest that the analyzed cytokines may play a proinflammatory role in the end stages of lung diseases, but further studies are needed to evaluate whether these cytokines could be used as biomarkers in this group of patients. |
| Databáze: | OpenAIRE |
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