Hyperglycemia and Adverse Pregnancy Outcome Study: Neonatal Glycemia
| Autor: | Boyd E, Metzger, Bengt, Persson, Lynn P, Lowe, Alan R, Dyer, J Kennedy, Cruickshank, Chaicharn, Deerochanawong, Henry L, Halliday, Anselm J, Hennis, Helen, Liley, Pak C, Ng, Donald R, Coustan, David R, Hadden, Moshe, Hod, Jeremy J N, Oats, Elisabeth R, Trimble, J, King |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty medicine.medical_treatment Hypoglycemia Infant Newborn Diseases Pregnancy Risk Factors Internal medicine Diabetes mellitus medicine Hyperinsulinemia Humans Insulin Glucose tolerance test C-Peptide medicine.diagnostic_test business.industry Neonatal hypoglycemia Glucose Measurement Infant Newborn Pregnancy Outcome Glucose Tolerance Test medicine.disease Pregnancy Complications Endocrinology Hyperglycemia Pediatrics Perinatology and Child Health Female business |
| Zdroj: | Pediatrics. 126:e1545-e1552 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.2009-2257 |
| Popis: | OBJECTIVE: The goal was to describe the temporal pattern of neonatal plasma glucose levels and associations with maternal glucose levels, cord serum C-peptide levels, and neonatal size and adiposity. METHODS: A total of 17 094 mothers and infants were included in the Hyperglycemia and Adverse Pregnancy Outcome Study (15 centers in 9 countries). Mothers underwent a 75-g, 2-hour, oral glucose tolerance test (OGTT) at 24 to 32 weeks of gestation. Cord blood and neonatal blood samples were collected. Biochemical neonatal hypoglycemia was defined as glucose levels of RESULTS: Plasma glucose concentrations were stable during the first 5 hours after birth. Maternal glucose levels were weakly positively associated with biochemical neonatal hypoglycemia (odds ratios: 1.07–1.14 for 1-SD higher OGTT glucose levels). Frequency of neonatal hypoglycemia was higher with higher cord C-peptide levels (odds ratio: 11.6 for highest versus lowest C-peptide category). Larger and/or fatter infants were more likely to have hypoglycemia (P < .001), and infants with hypoglycemia tended to have a higher frequency of cord C-peptide levels of >90th percentile. CONCLUSIONS: Mean neonatal plasma glucose concentrations varied little in the first 5 hours after birth, which suggests normal postnatal adjustment. Biochemical and clinical hypoglycemia were weakly related to maternal OGTT glucose measurements but were strongly associated with elevated cord serum C-peptide levels. Larger and/or fatter infants were more likely to develop hypoglycemia and hyperinsulinemia. These relationships suggest physiologic relationships between maternal glycemia and fetal insulin production. |
| Databáze: | OpenAIRE |
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