Lack of Adherence to Isoniazid Chemoprophylaxis in Children in Contact with Adults with Tuberculosis in Southern Ethiopia
| Autor: | Luis E. Cuevas, Kefyalew T. Garie, Mohammed A. Yassin |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Rural Population Bacterial Diseases Pediatrics Epidemiology Antitubercular Agents lcsh:Medicine Disease Medicine Prospective Studies lcsh:Science Child Pediatric Epidemiology Prospective cohort study Multidisciplinary Incidence (epidemiology) Infectious Diseases Child Preschool Chemoprophylaxis Female Public Health medicine.symptom Research Article medicine.medical_specialty Tuberculosis Adolescent Infectious Disease Control Asymptomatic Infectious Disease Epidemiology parasitic diseases Isoniazid Humans Tuberculosis Pulmonary Biology Population Biology business.industry lcsh:R Infant Tropical Diseases (Non-Neglected) medicine.disease Public Health Practice Patient Compliance lcsh:Q Ethiopia Preventive Medicine Contact Tracing business Contact tracing |
| Zdroj: | PLoS ONE PLoS ONE, Vol 6, Iss 11, p e26452 (2011) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0026452 |
| Popis: | Setting Hawassa, Southern Region of Ethiopia. Objectives To determine compliance to isoniazid (INH) preventive therapy (IPT) and its effectiveness in preventing (TB) disease in children in contact with adults with pulmonary TB (PTB). Design This was a prospective cohort study of children 5 years old were given advice but did not receive IPT, as recommended by the National TB control programme. Compliance to IPT and incidence of clinical TB were determined monthly for six months and then quarterly for up to 30 months. Results One hundred and eighty four children in contact with 83 smear-positive PTB cases were identified. Eighty two were ≤5 and 102>5 years old. Only 27 (33%) of 82 children given IPT took it for >4 months and 10 (12%) completed the 6-month course. The main reason for non-compliance was the perception that drugs were not necessary when the child was healthy. Eleven children (all except one >5 years old) developed symptoms of TB disease and initiated treatment, resulting in an incidence of 28.6 cases for all and 53.5 for children >5 years old per 1000 children-year. Conclusion Compliance to IPT in children is poor in Southern Region of Ethiopia and this was associated with the parents' perception of the low importance of chemoprophylaxis in asymptomatic children. Poor compliance might be an important barrier for the wider implementation of IPT. Trial Registration Clinicaltrials.gov NCT00456469 |
| Databáze: | OpenAIRE |
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