| Autor: |
Thomas Aparicio, Sandrine Hiret, P.L. Etienne, R. Desgrippes, V. Lebrun-Ly, Y. Rinaldi, F. Hocine, L. Mineur, M. Pauwels, M. Van den Eynde, J.J. Martin, J. Cretin, Jérôme Desramé, Eric Terrebonne, L. Cany, Anthony Turpin, Emilie Barbier, Claire Falandry, O. Bouche, L. Mosser |
| Přispěvatelé: |
UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service d'oncologie médicale, UCL - (SLuc) Service d'hépato-gastro-entérologie |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Annals of Oncology, Vol. 32, no./, p. S535 (2021) |
| ISSN: |
0923-7534 |
| Popis: |
Background Colon adenocarcinoma occurs mainly in older patients (pts). Oxaliplatin based adjuvant chemotherapy has demonstrated an improvement on disease-free survival (DFS) after a stage III colon cancer resection in young pts. Nevertheless, the benefit of adjuvant chemotherapy is matter of debate in old pts. Methods The purpose of ADAGE trial is to compare the DFS obtain with oxaliplatin combined with fluoropyrimidine (F) to F alone in fit pts over 70 years (group 1) and F to observation in frail pts (group 2) after resection of a stage III colon cancer. We here report a preliminary tolerance analysis on 50% of the first pts enrolled in the study. Results The analysis was performed on 491 pts (378 in group 1 and 113 in group 2). Main pts characteristics were respectively for the group 1 and 2: male in 57% and 50%, median age of 76 and 83 years, ECOG=0 in 59% and 29%, abnormal IADL in 23% and 62%, no caregiver in 26% and 28%, fall ≤6 months in 9% and 14%, depression possible 28% and 40%, fail of one-leg balance in 20% and 59%, impaired cognition in 21% and 38%, G8 score |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
