Response of Several Adrenal Steroids to ACTH Stimulation in Essential Hypertension
| Autor: | M. Honda, G. Nowac, F.H. Messerli, G. P. Guthrie, Wojciech Nowaczynski, Jacques Genest, O. Kuchel |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism Cortodoxone Clinical Biochemistry Essential hypertension Biochemistry chemistry.chemical_compound Endocrinology Adrenocorticotropic Hormone Adrenal Cortex Hormones Corticosterone Internal medicine Adrenal Glands Renin–angiotensin system Hydroxyprogesterones medicine Humans Secretion Desoxycorticosterone Aldosterone Acth stimulation Progesterone Sodium Biochemistry (medical) Plasma levels Middle Aged medicine.disease Kinetics 17-alpha-Hydroxyprogesterone chemistry Hypertension Potassium Female |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 44:264-272 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Plasma concentrations of progesterone (P), deoxycorticosterone (DOC), 17-hydroxyprogesterone (17-OH P), corticosterone (B), deoxycortisol (S), cortisol (F), and aldosterone were measured in 8 control subjects and in 10 patients with low and normal renin essential hypertension (EH) before and 4 and 8 h after an iv infusion of 25 units of ACTH. Secretion rates of 18-hydroxy-11-deoxycorticosterone (18-OH DOC) were measured for the 24 h prior to and the day of the ACTH infusions. The hypertensive patients had significantly higher plasma levels of aldosterone, DOC and S after ACTH than the controls, whereas plasma B levels were significantly lower. The low renin subgroup considered separately had significantly higher plasma levels of aldosterone and DOC than controls, and higher levels of B and lower levels of F than the normal renin subgroup in response to ACTH. Although not significantly different, the plasma levels of P and the secretion rate of 18-OH DOC tended to be higher, and plasma 17-OH P and F levels lower after ACTH in patients with EH than in controls. The low renin subgroup tended to have the highest plasma S levels and 18-OH DOC secretory rates and lowest F levels. Estimations of adrenal 11beta-hydroxylating efficiency in response to ACTH in patients and controls by plasma steroid ratios revealed significantly lower B/DOC ratios in both low and normal renin patients compared to controls, supported by somewhat lower F/S ratios in these patients, especially those in the low renin subgroup. Altered 17-hydroxylating efficiency seen by significantly lower 17-OH P/P ratios were also found in those with EH, supported by somewhat lower F/B and S/DOC ratios in these patients, agian especially in the low renin subgroup. These data are compatible with a pattern of altered adrenocortical steroid biosynthesis in essential hypertension bearing features similar to adrenal 11beta and 17alpha-hydroxylation deficiencies. |
| Databáze: | OpenAIRE |
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