Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis
| Autor: | Lu Chen, Han-Min Liu, Jing Liu, Tinghong Ye, Hua Zhang, Scott L. Friedman, Xia Xiao, Zhongwei Cao, Yutian Chen, Chunxue Zhang, Xingming Huang, Yafeng Ren, Yue Deng, Bi-Sen Ding, Bin Chen, Liping Chen, Ting Bai, Dong-Bo Wu, Yongyuan Ma, Wei Jiang, Xiaoqiang Tang, Yilin Zhao, Xinying Cheng |
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| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
Nonalcoholic steatohepatitis Cirrhosis Chronic hepatic business.industry Liver fibrosis General Medicine medicine.disease Bioinformatics digestive system digestive system diseases Liver regeneration Molecular network Non-alcoholic Fatty Liver Disease Fibrosis medicine Humans Vascular niche business |
| Zdroj: | Science Translational Medicine. 13 |
| ISSN: | 1946-6242 1946-6234 |
| DOI: | 10.1126/scitranslmed.abd1206 |
| Popis: | Chronic hepatic diseases such as nonalcoholic steatohepatitis (NASH) suppress liver regeneration and lead to fibrosis and cirrhosis. Decoding the cellular and molecular network underlying this fibrotic maladaptation might aid in combatting NASH, a growing health challenge with no approved therapies. Here, we used multiomics analysis of human cirrhotic liver, a Western diet– and carbon tetrachloride (CCl |
| Databáze: | OpenAIRE |
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