Bariatric Endocrinology: Principles of Medical Practice
| Autor: | Miguel Gonzalez Ahumada, Tiphani Martinez, Jessica Quinonez-Weislow, Beth Blaha, J. Michael Gonzalez-Campoy, Ayesha Ebrahim, Conor Richardson, Andrea Pierson, Maria Ransom, David Gonzalez-Cameron, Pamela Strobel, Bruce W. Richardson |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
lcsh:RC648-665 Endocrine and Autonomic Systems business.industry Endocrinology Diabetes and Metabolism Adipose tissue Disease Review Article Overweight medicine.disease Obesity lcsh:Diseases of the endocrine glands. Clinical endocrinology Adiposopathy Endocrinology Orexigenic Internal medicine medicine Hyperinsulinemia Ghrelin medicine.symptom business medicine.drug |
| Zdroj: | International Journal of Endocrinology, Vol 2014 (2014) International Journal of Endocrinology |
| ISSN: | 1687-8345 1687-8337 |
| Popis: | Obesity, is a chronic, biological, preventable, and treatable disease. The accumulation of fat mass causes physical changes (adiposity), metabolic and hormonal changes due to adipose tissue dysfunction (adiposopathy), and psychological changes. Bariatric endocrinology was conceived from the need to address the neuro-endocrinological derangements that are associated with adiposopathy, and from the need to broaden the scope of the management of its complications. In addition to the well-established metabolic complications of overweight and obesity, adiposopathy leads to hyperinsulinemia, hyperleptinemia, hypoadiponectinemia, dysregulation of gut peptides including GLP-1 and ghrelin, the development of an inflammatory milieu, and the strong risk of vascular disease. Therapy for adiposopathy hinges on effectively lowering the ratio of orexigenic to anorexigenic signals reaching the the hypothalamus and other relevant brain regions, favoring a lower caloric intake. Adiposopathy, overweight and obesity should be treated indefinitely with the specific aims to reduce fat mass for the adiposity complications, and to normalize adipose tissue function for the adiposopathic complications. This paper defines the principles of medical practice in bariatric endocrinology—the treatment of overweight and obesity as means to treat adiposopathy and its accompanying metabolic and hormonal derangements. |
| Databáze: | OpenAIRE |
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