Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity
| Autor: | Yubo Zhou, Xu Gaoya, Jia Li, Jun Li, K. A. Eshbakova, Shamansur S. Sagdullaev, Haji Akber Aisa, Khamidulla Kamoldinov |
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| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Plant Science Horticulture Sesquiterpene Plant Roots 01 natural sciences Biochemistry chemistry.chemical_compound Mogoltacin Coumarins Ic50 values Molecular Biology Ferula Apiaceae Molecular Structure biology Traditional medicine 010405 organic chemistry Chemistry General Medicine biology.organism_classification 0104 chemical sciences Phytochemical Sesquiterpenes 010606 plant biology & botany |
| Zdroj: | Phytochemistry. 187:112705 |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/j.phytochem.2021.112705 |
| Popis: | Phytochemical study on the ethanolic extract of the dried roots of Ferula samarkandica Korovin led to the isolation of nine undiscribed sesquiterpene coumarins, samarcandicins A−I, along with thirteen known sesquiterpene coumarins. Their structures were characterized by detailed spectroscopic analysis including NMR and HR-ESI-MS. Mogoltacin and nevskin exhibited high inhibitory activity against MV-4-11 cell with IC50 values of 3.94 ± 0.06 μM and 3.87 ± 0.10 μM, respectively, and nevskin and feshurin showed high inhibitory activity against mino cell with IC50 values of 1.48 ± 0.06 μM and 7.88 ± 0.60 μM, respectively. |
| Databáze: | OpenAIRE |
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