Improved Dissolution and Oral Bioavailability of Celecoxib by a Dry Elixir System
| Autor: | Dong-Jin Jang, Sung Tae Kim, Jun-Pil Jee, Sang Yeob Park, Kyeongsoon Kim, Taeyong Sim, Da A Yang, Dongjin Kang, Dae-Young Kim, Kwan Hyung Cho |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
Drug Materials science media_common.quotation_subject Biomedical Engineering Bioengineering 030226 pharmacology & pharmacy Dosage form 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine heterocyclic compounds General Materials Science Solubility skin and connective tissue diseases Dissolution media_common Ethanol Chromatography organic chemicals General Chemistry Condensed Matter Physics Elixir Bioavailability chemistry 030220 oncology & carcinogenesis Celecoxib lipids (amino acids peptides and proteins) medicine.drug |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 18:1482-1486 |
| ISSN: | 1533-4880 |
| DOI: | 10.1166/jnn.2018.14885 |
| Popis: | The purpose of this study was to develop and evaluate a dry elixir (DE) system for enhancing the dissolution rate and oral bioavailability of celecoxib. DE system has been used for improving solubility, oral bioavailability of poorly water-soluble drugs. The encapsulated drugs or solubilized drugs in the matrix are rapidly dissolved due to the co-solvent effect, resting in both an enhanced dissolution and bioavailability. DEs containing celecoxib were prepared by spray-drying method and characterized by morphology, drug/ethanol content, drug crystallinity, dissolution rate and oral bioavailability. The ethanol content and drug content in DE system could be easily altered by controlling the spraydrying conditions. The dissolution profile of celecoxib from DE proved to be much higher than that of celecoxib powder due to the nano-structured matrix, amorphous state and encapsulated ethanol. The bioavailability of celecoxib from DEs was compared with celecoxib powder alone and commercial product (Celebrex®) in rats. In particular, blood concentrations of celecoxib form DE formulation were much greater than those of native celecoxib and market product. The data demonstrate that the DE system could provide an useful solid dosage form to enhance the solubility, dissolution rate and oral bioavailability of celecoxib. |
| Databáze: | OpenAIRE |
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