Independent Factors of Changes of Ankle-Brachial Index in Peripheral Arterial Occlusive Disease in Elderly Patients with or without Diabetes
| Autor: | Monika Kadłubowska, Sylwia Krzemińska, Bożena Krawczyk, Elżbieta Glądys, Ewelina Bąk, Anna Michalik, Czeslaw Marcisz, Tomasz Fiałkowski, Agnieszka Drosdzol-Cop, Dorota Dobrzyn-Matusiak |
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| Rok vydání: | 2016 |
| Předmět: |
ankle-brachial index
peripheral arterial disease diabetes elderly Male medicine.medical_specialty Health Toxicology and Mutagenesis lcsh:Medicine Renal function Arterial Occlusive Diseases Type 2 diabetes Disease 030204 cardiovascular system & hematology Fibrinogen Article Peripheral Arterial Disease 03 medical and health sciences 0302 clinical medicine Blood serum Risk Factors Diabetes mellitus Internal medicine Humans Medicine Ankle Brachial Index 030212 general & internal medicine Aged business.industry lcsh:R Public Health Environmental and Occupational Health Middle Aged medicine.disease Surgery body regions Diabetes Mellitus Type 2 Lower Extremity Cardiology Female Poland business Body mass index medicine.drug |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 13, Iss 11, p 1103 (2016) International Journal of Environmental Research and Public Health; Volume 13; Issue 11; Pages: 1103 |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph13111103 |
| Popis: | Peripheral arterial disease (PAD) belongs to the commonly-occurring pathologies associated with elderly age. A simple tool for defining the severity of PAD is the ankle-brachial index (ABI). The purpose of this research was to determine independent factors of changes of ABI in elderly patients with occlusive PAD disease (PAOD) with and without diabetes. The research was carried out on 49 elderly patients with PAOD, including 29 patients with type 2 diabetes, and 20 patients without diabetes. The concentration of interleukin-6 (IL-6), E-selectin, fibrinogen, and C-reactive protein (CRP) in the blood serum was marked. In all patients, the independent factors of changes of ABI were determined with the use of the multiple logistic regression analysis. Our results show that in the group of patients with PAOD suffering from diabetes, it was demonstrated that the ABI was related to age, the duration of the symptoms of PAD, body mass index (BMI), low-density lipoprotein cholesterol, fibrinogen, and sex (determination coefficient R2 = 0.699). In patients with PAOD without diabetes, the ABI was related to age, the duration of the symptoms of PAD, the levels of CRP, E-selectin, high-density lipoprotein cholesterol, and the glomerular filtration rate(determination coefficient R2 = 0.844). We conclude that in elderly patients with PAOD with and without diabetes, the participation of independent factors related to the ABI is diversified; in patients with diabetes, the concentration of IL-6 and fibrinogen is lower, and the concentration of E-selectin is higher than in patients without diabetes. |
| Databáze: | OpenAIRE |
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