Decreased Dexamethasone Suppression in endogenously depressed patients with normal basal plasma levels of cortisol
| Autor: | Frank Gasparini, Susanna Goldstein, Jacques Vital-Herne, Uriel Halbreich, Byung-Jo Kang, Simona Naor, Gregory M. Asnis |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Cortisol awakening response Hydrocortisone Pituitary-Adrenal System Dexamethasone Basal (phylogenetics) Internal medicine medicine Humans Biological Psychiatry Aged Depressive Disorder business.industry Plasma levels Middle Aged medicine.disease Dexamethasone suppression Endocrinology Dexamethasone suppression test Endogenous depression Major depressive disorder Female business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Biological Psychiatry. 21:1434-1437 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/0006-3223(86)90336-7 |
| Popis: | The hypothalamic-pituitary-adrenal (HPA) system has been reported to be abnormal in at least some patients with major depressive disorder (MDD) and in particular in endogenous depression (ED) (Sachar et al. 1973; Carroll et al. 1981; Stokes et al. 1984; Halbreich et al. 1985a.b). The most studied variables of this system have been basal cortisol levels and the Dexamethasone Suppression Test (DST). Nonsuppression of cortisol in response to dexamethasone is generally assumed to be an indicator of hyperactivity of the HPA system and is frequently reported as being almost synonymous to hypersecretion of cortisol (e.g., Carroll et al. 1976). Recently, there have been several reports that abnormal DST and elevated basal levels of cortisol may only partially overlap with each other (Asnis et al. 1981; Stokes et al. 1984; Holsboer |
| Databáze: | OpenAIRE |
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