Probiotics and growth in preterm infants: A randomized controlled trial, PREMAPRO study

Autor: Hélène Gauthier, Estelle Jumas-Bilak, Olivier Claris, Anne Beissel, Jean-Charles Picaud, Evelyne Decullier, Aurélien Jacquot, Gilles Cambonie, Christian Kempf, Odile Pidoux, G Putet, L. Beck, Stéphane Haÿs, E. Lachambre
Přispěvatelé: Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-CHU Saint-Etienne-Hospices Civils de Lyon (HCL)-CHU Grenoble, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Ecologie des systèmes marins côtiers (Ecosym), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS), Nestlé France, Université de Montpellier (UM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RH), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-CHU Saint-Etienne-Hospices Civils de Lyon (HCL)-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
Pediatrics
Critical Care and Intensive Care Medicine
law.invention
Probiotic
Feces
0302 clinical medicine
Randomized controlled trial
law
Necrotizing enterocolitis
Birth Weight
Infant
Very Low Birth Weight
030212 general & internal medicine
Prospective Studies
Infant Nutritional Physiological Phenomena
Bifidobacterium
Nutrition and Dietetics
biology
Incidence
Gestational age
3. Good health
Treatment Outcome
Body Composition
Female
Dietary Proteins
Safety
Prematurity
Infant
Premature
medicine.medical_specialty
Birth weight
Gestational Age
Placebo
03 medical and health sciences
Bifidobacterium animalis
Double-Blind Method
Enterocolitis
Necrotizing
030225 pediatrics
Internal medicine
Sepsis
medicine
Humans
Gut microflora
Intention-to-treat analysis
Milk
Human
business.industry
Probiotics
Infant
medicine.disease
biology.organism_classification
Bifidobacterium longum
Diet
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Zdroj: Clinical Nutrition
Clinical Nutrition, Elsevier, 2016, 35 (4), pp.802-811. ⟨10.1016/j.clnu.2015.06.006⟩
ISSN: 0261-5614
Popis: Summary Background & aims Recent studies have suggested that the gut microflora has metabolic effects. We aimed to evaluate postnatal growth in preterm infants who received different probiotic supplements, and to assess the safety of probiotic administration. Methods This prospective, randomized, double-blind, controlled trial was performed at three tertiary care neonatal units. Preterm infants were randomly assigned to receive daily supplementation over 4–6 weeks with placebo (group C) or probiotics (group P). Group P comprised three subgroups: P1 received Bifidobacterium lactis , P2 received Bifidobacterium longum , and P3 received B. lactis and B. longum . We assessed postnatal growth during the supplementation period and up to a corrected gestational age (GA) of 41 weeks when body composition was assessed using whole-body dual-energy X-ray absorptiometry. Aerobic and anaerobic blood cultures were performed on suspicion of late-onset sepsis. Results The study comprised 199 preterm infants with a mean GA of 29.1 ± 1.4 weeks and a mean birth weight of 1173 ± 210 g, who received a placebo (group C, n = 52) or probiotics (group P, n = 147) from the first week of life. At the end of the supplementation period, no statistically significant differences were seen between the groups in relation to the mean body weight (group C = 1906 ± 23 g, group P = 1875 ± 14 g, p = 0.25), length, or head circumference. The incidence rates of necrotizing enterocolitis and late-onset sepsis were similar in the two groups. At the corrected GA of 41 weeks, there were no differences between the groups with respect to anthropometric measurements or body composition analysis. Conclusions Preterm infants receiving Bifidobacterium supplements did not exhibit better postnatal growth compared with those who received placebo treatment. No adverse effects were associated with probiotic administration. Registered under ClinicalTrials.gov Identifier no. NCT01379417.
Databáze: OpenAIRE
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