Single-Point Cardiac Troponin T at Coronary Care Unit Discharge after Myocardial Infarction Correlates with Infarct Size and Ejection Fraction
| Autor: | Elena Bonini, Mauro Panteghini, Raffaele Giubbini, Claudio Cuccia, Graziella Bonetti, Franca Pagani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Clinical Biochemistry Hospital Departments Myocardial Infarction Troponin T Troponin complex Spect imaging Internal medicine medicine Creatine Kinase MB Form Humans cardiovascular diseases Myocardial infarction Creatine Kinase Aged Tomography Emission-Computed Single-Photon Ejection fraction biology business.industry Biochemistry (medical) Stroke Volume Middle Aged medicine.disease Troponin Isoenzymes biology.protein Cardiology Coronary care unit Female Myocardial infarction diagnosis business |
| Zdroj: | Scopus-Elsevier |
| Popis: | Background: One of the major concerns in replacing creatine kinase MB (CK-MB) with cardiac troponins is the lack of evidence of the ability of troponins to estimate the size of acute myocardial infarction (AMI). We investigated the ability of a single measurement of cardiac troponin T (cTnT) at coronary care unit (CCU) discharge to estimate infarct size and assess left ventricular (LV) function in AMI patients. Methods: We studied 65 AMI patients in whom infarct size was estimated by CK-MB peak concentrations and gated single-photon emission computed tomography (SPECT) myocardial perfusion using technetium-99m sestamibi and LV function by SPECT imaging. Measurements of cTnT and SPECT were performed 72 h (median) after admission (range, 40–160 h). SPECT was also repeated 3 months later. Results: We found a significant correlation between cTnT and both the peak CK-MB concentrations (r = 0.76; P 2.98 μg/L predicted a LVEF Conclusions: A single cTnT measurement at CCU discharge after AMI is useful as a noninvasive estimate of infarct size and for the assessment of LV function in routine clinical setting. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|