Results of salvage therapy after failure of initial treatment for advanced olfactory neuroblastoma
| Autor: | Hyun Jik Kim, Kyung Soo Kim, Heui Jong Kim, Hun Suk Lee, Joo-Heon Yoon, Euisok Jung, Hyung Ju Cho |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Nose Neoplasms Esthesioneuroblastoma Olfactory Salvage therapy Nose neoplasm Disease-Free Survival Metastasis Radiotherapy High-Energy Antineoplastic Combined Chemotherapy Protocols medicine Humans Child Survival rate Aged Retrospective Studies Salvage Therapy Olfactory Neuroblastoma business.industry Neck dissection Middle Aged Prognosis medicine.disease Surgery Radiation therapy Otorhinolaryngology Neck Dissection Female Nasal Cavity Neoplasm Recurrence Local Oral Surgery Recurrent Olfactory Neuroblastoma business |
| Zdroj: | Journal of Cranio-Maxillofacial Surgery. 36:47-52 |
| ISSN: | 1010-5182 |
| DOI: | 10.1016/j.jcms.2007.08.004 |
| Popis: | Summary Introduction Olfactory neuroblastoma is a very aggressive tumour with high rates of locoregional recurrence and distant metastasis. Therefore, salvage therapy plays an important role in control of these neoplasms. In this study, we present our experience and treatment outcomes for salvage therapy in patients with recurrent olfactory neuroblastoma. Material and methods We retrospectively analysed 17 patients treated for advanced olfactory neuroblastoma during the last 15 years. Results The disease-free 5-year survival rate was 48% in all patients and 42% in the 17 patients with recurrence or distant metastasis. Salvage therapy was performed in 6 of 8 patients with recurrence or metastasis and proved successful in 50% of them. In the patients with locoregional recurrence, the success rate of salvage radiotherapy plus neck dissection was superior to salvage chemotherapy alone. In addition, 17% of the patients with distant metastasis after initial treatment died after salvage therapy. In 15% of patients with a clinical stage N0 at initial diagnosis, nodal recurrence developed and was successfully treated with salvage therapy. Conclusion Complete surgical resection, including craniofacial resection and postoperative radiotherapy without elective neck dissection, is the preferred approach in the treatment of advanced olfactory neuroblastoma. In locoregional recurrence, successful salvage therapy may include selective neck dissection and radiotherapy, but in cases of distant metastasis, the prognosis was poor. |
| Databáze: | OpenAIRE |
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