Asynchronous Differentiation of CD8 T Cells That Recognize Dominant and Cryptic Antigens
| Autor: | Claude Perreault, Richard LeBlanc, Mark J. Cameron, Chantal Baron, Marie-Christine Meunier, Etienne Caron, Caroline Côté, David J. Kelvin, Vincent Rineau |
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| Rok vydání: | 2006 |
| Předmět: |
T cell
H-Y Antigen Immunology Epitopes T-Lymphocyte Hemagglutinin Glycoproteins Influenza Virus Mice Inbred Strains Streptamer CD8-Positive T-Lymphocytes Biology Antibodies Epitopes Mice Interleukin 21 medicine Animals Immunology and Allergy Cytotoxic T cell IL-2 receptor Antigen-presenting cell Cell Proliferation Immunodominant Epitopes CD28 Cell Differentiation Natural killer T cell Cell biology Kinetics medicine.anatomical_structure Female |
| Zdroj: | The Journal of Immunology. 177:8466-8475 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.177.12.8466 |
| Popis: | Restriction of T cell responses to a few epitopes (immunodominance) is a central feature of immune responses. We analyzed the entire transcriptome of effector CD8 T cells specific for a dominant (H7a) and a cryptic (HY) mouse Ag and performed a longitudinal analysis of selected T cell differentiation markers. We found that Ag specificity had a relatively modest influence on the repertoire of genes that are transcriptionally modulated by the CD8 T cell differentiation program. Although the differentiation programs of anti-H7a and anti-HY T cells were similar, they did not progress simultaneously. The expansion peak of anti-H7a T cells was reached on day 10 while that of anti-HY T cells was attained on days 15–20. Between days 10 and 20, anti-H7a T cells were in the contraction phase and anti-HY T cells in the expansion phase. Furthermore, expansion and development of effector function were well-synchronized in anti-H7a T cells but were disconnected in anti-HY T cells. We propose that, by leading to selective expansion of the fittest CD8 T cells, immunodominance may be beneficial to the host. Inhibition of the T cell response to cryptic Ag would ensure that host resources (APC, cytokines) for which T cells compete are devoted to T cells with the best effector potential. One implication is that favoring expansion of the fittest effector T cells in general may be more important than increasing the diversity of the T cell repertoire. |
| Databáze: | OpenAIRE |
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