Faecal Calprotectin in Assessment of Mucosal Healing in Adults with Inflammatory Bowel Disease: A Meta-Analysis
| Autor: | Małgorzata Krzystek-Korpacka, Katarzyna Neubauer, Radosław Kempiński, Mariusz A. Bromke |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
faecal calprotectin Colonoscopy Disease Review Gastroenterology Inflammatory bowel disease mucosal healing 03 medical and health sciences 0302 clinical medicine fluids and secretions inflammatory bowel disease Internal medicine medicine diagnostics medicine.diagnostic_test business.industry Incidence (epidemiology) digestive oral and skin physiology General Medicine medicine.disease Ulcerative colitis Faecal calprotectin meta-analysis 030220 oncology & carcinogenesis Mucosal healing Meta-analysis Medicine 030211 gastroenterology & hepatology business |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 10, Iss 2203, p 2203 (2021) |
| ISSN: | 2077-0383 |
| Popis: | Achieving mucosal healing in patients with inflammatory bowel disease is related to a higher incidence of sustained clinical remission and it translates to lower rates of hospitalisation and surgery. The assessment methods of disease activity and response to therapy are limited and mainly rely on colonoscopy. This meta-analysis reviews the effectiveness of using faecal calprotectin as a marker for mucosal healing in inflammatory bowel disease. Two meta-analyses were conducted in parallel. The analysis on the use of faecal calprotectin in monitoring mucosal healing in colonic Crohn’s disease is based on 16 publications (17 studies). The data set for diagnostic values of faecal calprotectin in ulcerative colitis is composed of 35 original publications (total 49 studies). The DOR for the use of faecal calprotectin in Crohn’s disease is estimated to be 11.20 and the area under the sROCis 0.829. In cases of ulcerative colitis, the DOR is 14.48, while the AUC sROC is 0.858. Heterogeneity of the studies was moderatetosubstantial. Collected data show overall good sensitivity and specificity of the faecal calprotectin test, as well as a good DOR. Thus, monitoring of mucosal healing with a non-invasive faecal calprotectin test may represent an attractive option for physicians and patients with inflammatory bowel disease. |
| Databáze: | OpenAIRE |
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