Unique Inflammatory Changes in Exocrine and Endocrine Pancreas in Enterovirus-Induced Fulminant Type 1 Diabetes
| Autor: | Soroku Yagihashi, Yoichi Oikawa, Tetsuro Kobayashi, Erika Jimbo, Kaoru Aida, Tetsuya Babazono, Tomoyasu Fukui, Junnosuke Miura, Mikako Takita, Akira Shimada |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Ductal cells Endocrinology Diabetes and Metabolism Clinical Biochemistry CXCR3 Biochemistry Sensitivity and Specificity Severity of Illness Index Sampling Studies Receptors Interleukin-8A Hospitals University Islets of Langerhans Young Adult Endocrinology Japan Internal medicine medicine Enterovirus Infections CXCL10 Endocrine system Humans CXC chemokine receptors Enterovirus Retrospective Studies business.industry CD11 Antigens Pancreatitis Acute Necrotizing Biochemistry (medical) Biopsy Needle Middle Aged medicine.disease Immunohistochemistry Pancreas Exocrine medicine.anatomical_structure Diabetes Mellitus Type 1 Capsid Proteins Female Pancreas business Insulitis CD8 Biomarkers |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 104(10) |
| ISSN: | 1945-7197 |
| Popis: | Context There are scant reports on the pathological changes of the exocrine and endocrine pancreas in fulminant type 1 diabetes mellitus (FT1DM). Objective To clarify the distinct pathological changes in the exocrine as well as the endocrine pancreas shortly after onset of diabetes in FT1DM. Design The exocrine and endocrine pancreases of 3 patients with FT1DM and 17 nondiabetic controls were immunohistochemically examined for islet and exocrine tissue inflammation, infiltrating mononuclear cell (MNC) CD subtype, enterovirus capsid protein 1 (VP1) localization, and CXC chemokine ligand 10 (CXCL10) and CXC chemokine receptor 3 (CXCR3) expressions. Results The median frequency of insulitis in the 3 FT1DM pancreases was 60%. In the nondiabetic control pancreases, no insulitis was observed. In the islets of FT1DM, the numbers of CD45+, CD3+, CD8+, CD68+, and CD11c+ MNCs were significantly higher than those of the control group. In the exocrine pancreas of FT1DM, the numbers of CD3+ T cells, CD8+ T cells, CD68+ macrophages, and CD11c+ dendritic cells were significantly higher than those of the control group. Infiltrating CD8+ T cells, CD68+ macrophages, and CD11c+ dendritic cells were observed around exocrine acinar cells in FT1DM. There was a close association between VP1 and CXCL10 expression in pancreatic exocrine ductal cells and acinar cells as well as islet cells in FT1DM. CXCL10+ exocrine cells were surrounded by CXCR3+ T cells. Conclusion The pathological findings suggested that suppression of the activated CXCL10–CXCR3 axis in the exocrine as well as the endocrine pancreas is a novel therapeutic target in FT1DM and possibly in enterovirus-associated acute-onset type 1 diabetes. |
| Databáze: | OpenAIRE |
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