Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes
| Autor: | Gülay Börekçi, Cemal Koray Ozer, Hakan Arslan, Cevdet Akbay, Nizami Duran |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
In vitro studies
Proteus vulgaris Pharmaceutical Science Microbial Sensitivity Tests Gram-Positive Bacteria 010402 general chemistry Enterobacter aerogenes Candida parapsilosis 01 natural sciences Article Thiourea derivatives Complexes Antibacterial activity Antifungal activity Lipophilicity Analytical Chemistry Microbiology Candida tropicalis lcsh:QD241-441 Anti-Infective Agents lcsh:Organic chemistry Nickel Yeasts Candida krusei Gram-Negative Bacteria Drug Discovery Physical and Theoretical Chemistry Candida albicans Molecular Structure biology Candida glabrata 010405 organic chemistry Chemistry Organic Chemistry Thiourea biology.organism_classification 3. Good health 0104 chemical sciences Chemistry (miscellaneous) Molecular Medicine Enterobacter cloacae Copper |
| Zdroj: | Molecules; Volume 14; Issue 1; Pages: 519-527 Molecules, Vol 14, Iss 1, Pp 519-527 (2009) Molecules |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules14010519 |
| Popis: | Five thiourea derivative ligands and their Ni 2+ and Cu 2+ complexes have been synthesized. The compounds were screened for their in vitro anti-bacterial activity using Gram-positive bacteria (two different standard strains of Staphylococcus aureus , Staphylococcus epidermidis , Enterococcus faecalis , Streptococcus pyogenes , Bacillus cereus ) and Gram-negative bacteria ( Esherichia coli , Pseudomonas aeruginosa , Enterobacter cloacae , Proteus vulgaris , Enterobacter aerogenes ) and in vitro anti-yeast activity ( Candida albicans , Candida krusei , Candida glabrata , Candida tropicalis , Candida parapsilosis ). The minimum inhibitory concentration was determined for all ligands and their complexes. In vitro anti-yeast activity of both ligands and their metal complexes is greater than their in vitro anti-bacterial activity. The effect of the structure of the investigated compounds on the antimicrobial activity is discussed. Keywords: Thiourea derivatives; Complexes; Antibacterial activity; Antifungal activity |
| Databáze: | OpenAIRE |
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