T Cell Specificity: A Great Challenge in Chagas Disease
| Autor: | Karina A. Gómez, Fátima Ferragut, Gonzalo Raúl Acevedo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Chagas disease
T-Lymphocytes T cell Trypanosoma cruzi mouse model Immunology Antigens Protozoan T-Cell Antigen Receptor Specificity Context (language use) Review Genome purl.org/becyt/ford/1 [https] Mice medicine Animals Humans Immunology and Allergy Parasite hosting purl.org/becyt/ford/1.6 [https] HUMAN MODEL biology T CELL SPECIFICITY CHAGAS DISEASE MOUSE MODEL TRYPANOSOMA CRUZI RC581-607 biology.organism_classification medicine.disease T cell specificity human model Phenotype medicine.anatomical_structure Immunologic diseases. Allergy CD8 |
| Zdroj: | Frontiers in Immunology, Vol 12 (2021) CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Frontiers in Immunology |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2021.674078/full |
| Popis: | The CD4+ and CD8+ T cell immune response against T. cruzi, the parasite causing Chagas disease, are relevant for both parasite control and disease pathogenesis. Several studies have been focused on their phenotype and functionally, but only a few have drilled down to identify the parasite proteins that are processed and presented to these cells, especially to CD4+ T lymphocytes. Although approximately 10,000 proteins are encoded per haploid T. cruzi genome, fewer than 200 T cell epitopes from 49 T. cruzi proteins have been identified so far. In this context, a detailed knowledge of the specific targets of T cell memory response emerges as a prime tool for the conceptualization and development of prophylactic or therapeutic vaccines, an approach with great potential to prevent and treat this chronic disease. Here, we review the available information about this topic in a comprehensive manner and discuss the future challenges in the field. Fil: Ferragut, Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Acevedo, Gonzalo Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina Fil: Gomez, Karina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina |
| Databáze: | OpenAIRE |
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