Development, characterisation, stability study and antileukemic evaluation of nanoemulsions containing Astrocaryum aculeatum extract

Autor:	André Gündel, Aline Ferreira Ourique, Pablo Sebastian Britto de Oliveira, Andiara Prates Ramos, Francieli Guedes Pintos, Alencar Kolinski Machado, Priscila Marquezan Copetti, Michele Rorato Sagrillo, Samanta da Silva Gündel, Lauren Pappis, Fernanda Reis Favarin
Rok vydání:	2020
Předmět:	Astrocaryum aculeatum biology 010405 organic chemistry Stability study Chemistry Organic Chemistry Plant Science biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Food science
Zdroj:	Natural Product Research. 36:1321-1326
ISSN:	1478-6427 1478-6419
Popis:	The objective of this work was to produce and characterise nanoemulsions containing tucumã extract and to evaluate the performance of the nanostructure and the free compound regarding antitumor activity, cytotoxicity, and oxidative metabolism in NB4/APL cells. The nanoemulsions showed adequate physicochemical characteristics (average size approx. 200 nm, polydispersity index less than 0.3, negative zeta potential and acid pH) maintained stable up to 90 days of storage in refrigeration condition. The nanoformulations did not present protein corona formation. Blank nanoemulsion treatments showed moderate toxicity. Furthermore, the nanoemulsion loaded with extract showed better antileukemic results than the free extract. However, nanoemulsions can be promising carriers of natural compounds, emphasising their biological properties and constituting alternatives in treating diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2786f3bcca87a1a3125a5ba0412b66 https://doi.org/10.1080/14786419.2020.1862830 Zobrazit plný text záznamu