| Autor: |
Lijun He, Zhiyang Xie, Xing Long, Chaopeng Zhang, Chengyun He, Boyang Zhao, Fei Qi, Nan Zhang |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Process biochemistry (Barking, London, England). 121 |
| ISSN: |
1359-5113 |
| Popis: |
The B.1.617.2 (Delta) variant of concern is causing a new wave of infections in many countries. In order to better understand the changes of the SARS-CoV-2 mutation at the genetic level, we selected six mutations in the S region of the Delta variant compared with the native SARS-CoV-2 and get the conductance information of these six short RNA oligonucleotides groups by construct RNA: DNA hybrids. The electronic characteristics are investigated by the combination of density functional theory and non-equilibrium Green's function formulation with decoherence. We found that conductance is very sensitive to small changes in virus sequence. Among the 6 mutations in the Delta S region, D950N shows the largest change in relative conductance, reaching a surprising 4104.75%. These results provide new insights into the Delta variant from the perspective of its electrical properties. This may be a new method to distinguish virus variation and possess great research prospects. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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