A vitamin D, calcium and leucine-enriched whey protein nutritional supplement improves measures of bone health in sarcopenic non-malnourished older adults: The PROVIDE study

Autor: the PROVIDE Consortium, Hill, Tom R., Verlaan, Sjors, Biesheuvel, Egbert, Eastell, Richard, Bauer, Juergen M., Bautmans, Ivan, Brandt, Kirsten, Donini, Lorenzo M., Maggio, Marcello, Mets, Tony, Seal, Chris J., Wijers, Sander Lj, Sieber, Cornel, Cederholm, Tommy, Aspray, Terry J.
Přispěvatelé: Research in Geriatrics and Gerontology, Gerontology, Rehabilitation Research, Physical Medicine and Rehabilitation, Frailty in Ageing, Vriendenkring VUB, Geriatrics
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Aging
medicine.medical_treatment
Endocrinology
Diabetes and Metabolism
Parathyroid hormone
Bone remodeling
Insulin-like growth factor
0302 clinical medicine
Bone Density
Orthopedics and Sports Medicine
Vitamin D
intervention
Bone mineral
BMD
bone turnover
leucine
PROVIDE study
vitamin D
biology
Middle Aged
Micronutrient
Endokrinologi och diabetes
Osteocalcin
Female
PROVIDE Study
medicine.medical_specialty
Bone turnover
030209 endocrinology & metabolism
Intervention
Endocrinology and Diabetes
Bone and Bones
03 medical and health sciences
endocrinology
Double-Blind Method
Leucine
Internal medicine
medicine
Vitamin D and neurology
Humans
Muscle Strength
Muscle
Skeletal
Aged
business.industry
medicine.disease
Endocrinology
Whey Proteins
Sarcopenia
Dietary Supplements
biology.protein
Calcium
030101 anatomy & morphology
business
ISSN: 0171-967X
Popis: Alterations in musculoskeletal health with advanced age contribute to sarcopenia and decline in bone mineral density (BMD) and bone strength. This decline may be modifiable via dietary supplementation. To test the hypothesis that a specific oral nutritional supplement can result in improvements in measures of bone health. Participants (n 380) were participants of the PROVIDE study, a 13-week, multicenter, randomized, controlled, double-blind, 2 parallel-group study among non-malnourished older participants (≥ 65 years) with sarcopenia [determined by Short Physical Performance Battery (SPPB; 0-12) scores between 4 and 9, and a low skeletal muscle mass index (SMI; skeletal muscle mass/BW × 100) ≤ 37% in men and ≤ 28% in women using bioelectric impedance analysis] Supplementation of a vitamin D, calcium and leucine-enriched whey protein drink that comprises a full range of micronutrients (active; 2/day) was compared with an iso-caloric control. Serum 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), biochemical markers of bone formation (osteocalcin; OC, procollagen type 1 amino-terminal propeptide; P1NP) and resorption (carboxy-terminal collagen crosslinks; CTX), insulin like growth factor 1 (IGF-1) and total-body BMD were analysed pre- and post-intervention. Serum 25(OH)D concentrations increased from 51.1 ± 22.9 nmol/L (mean ± SD) to 78.9 ± 21.1 nmol/L in the active group (p
Databáze: OpenAIRE
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