The mineralocorticoid receptor antagonist eplerenone reduces renal interstitial fibrosis after long-term cyclosporine treatment in rat: antagonizing cyclosporine nephrotoxicity

Autor: Boye L. Jensen, Pernille Lund Hansen, Niels Marcussen, Peter Bie, Finn Thomsen Nielsen
Rok vydání: 2013
Předmět:
Male
medicine.medical_specialty
Immunosuppressive Agents/adverse effects
Renal function
Spironolactone
Kidney/drug effects
Kidney
Nephropathy
Nephrotoxicity
Rats
Sprague-Dawley
chemistry.chemical_compound
Mineralocorticoid receptor
Nephritis
Interstitial/chemically induced
Internal medicine
Renin
medicine
Animals
Drug Interactions
Cyclosporine/adverse effects
Longitudinal Studies
Aldosterone
Mineralocorticoid Receptor Antagonists
Fibrosis/chemically induced
business.industry
Calcineurin
Spironolactone/administration & dosage
Mineralocorticoid Receptor Antagonists/administration & dosage
medicine.disease
Fibrosis
Rats
Eplerenone
Treatment Outcome
Endocrinology
medicine.anatomical_structure
chemistry
Nephrology
Hypertension
Cyclosporine
Nephritis
Interstitial
business
Immunosuppressive Agents
Research Article
medicine.drug
Zdroj: Nielsen, F T, Jensen, B L, Hansen, P B, Marcussen, N & Bie, P 2013, ' The mineralocorticoid receptor antagonist eplerenone reduces renal interstitial fibrosis after long-term cyclosporine treatment in rat : antagonizing cyclosporine nephrotoxicity ', B M C Nephrology, vol. 14, no. 1, 42 . https://doi.org/10.1186/1471-2369-14-42
BMC Nephrology
ISSN: 1471-2369
DOI: 10.1186/1471-2369-14-42
Popis: Background: Chronic cyclosporine-(CsA)-mediated loss of kidney function is a major clinical problem in organ transplantation. We hypothesized that the mineralocorticoid receptor antagonist eplerenone (EPL) prevents chronic CsA-induced renal interstitial volume increase, tubule loss, and functional impairment in a rat model. Methods. Sprague-Dawley rats received CsA alone (15 mg/kg/d p.o.), CsA and EPL (approximately 100 mg/kg/day p.o.) or vehicle (control) for 12 weeks. At 11 weeks, chronic indwelling arterial and venous catheters were implanted for continuous measurements of arterial blood pressure (BP) and GFR (inulin clearance) in conscious, freely moving animals. Plasma was sampled for analysis and kidney tissue was fixed for quantitative stereological analyses. Results: Compared to controls, CsA-treatment reduced relative tubular volume (0.73±0.03 vs. 0.85±0.01, p
Databáze: OpenAIRE
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