Muscarinic autoreceptors of Torpedo electric organ are of the M1 subtype: evidence by radioligand binding using selective antagonists
| Autor: | A C Green, Michael J. Dowdall |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Muscarinic Antagonists Pharmacology Diamines Torpedo Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Radioligand Assay Internal medicine Muscarinic acetylcholine receptor Muscarinic acetylcholine receptor M4 Methoctramine medicine Animals Electric Organ Myocardium Muscarinic acetylcholine receptor M3 Parasympatholytics Muscarinic acetylcholine receptor M2 Muscarinic acetylcholine receptor M1 Pirenzepine Receptors Muscarinic Rats Quinuclidinyl Benzilate Endocrinology chemistry Autoreceptor medicine.drug |
| Zdroj: | Journal of neurochemistry. 58(2) |
| ISSN: | 0022-3042 |
| Popis: | The presynaptic muscarinic autoreceptor of Torpedo marmorata electric organ has been characterised by radioligand binding studies using the subtype-selective antagonists pirenzepine, (+)-telenzepine, methoctramine, and AF-DX 116. The presynaptic receptor had relatively high affinity for the M1 antagonists pirenzepine and (+)-telenzepine (Ki = 35 and 7 nM, respectively) and lower affinities for the M2 antagonists AF-DX 116 and methoctramine (Ki = 311 and 277 nM, respectively). Comparison of these binding data with those from an M2 receptor (rat heart membranes) assayed under identical conditions and with data in the recent literature suggests that the Torpedo muscarinic autoreceptor has a pharmacology most similar to the M1 pharmacological subtype of muscarinic acetylcholine receptor. |
| Databáze: | OpenAIRE |
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