Correlation between retinal nerve fiber layer thickness and IOP variation in glaucoma suspects and patients with primary open-angle glaucoma
| Autor: | Artur William Caldeira Abreu Veloso, Rafael V Merola, Yara C Sasso, Christy Veiga, Sebastião Cronemberger, Gustavo Scarpelli |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Intraocular pressure
medicine.medical_specialty genetic structures Open angle glaucoma Optic Disk Nerve fiber layer Glaucoma 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Nerve Fibers Ophthalmology Medicine Humans Intraocular Pressure 030304 developmental biology 0303 health sciences business.industry Retinal General Medicine Glaucoma suspect medicine.disease eye diseases medicine.anatomical_structure chemistry 030221 ophthalmology & optometry sense organs business Glaucoma Open-Angle Tomography Optical Coherence |
| Zdroj: | European journal of ophthalmology. 31(5) |
| ISSN: | 1724-6016 |
| Popis: | Purpose: To analyze the relationship between retinal nerve fiber layer thickness (RNFLT) and intraocular pressure (IOP) variation in glaucoma suspects (GS) and patients with primary open-angle glaucoma (POAG). Methods: Thirty-one GS and 34 POAG patients underwent ophthalmologic examination and 24-h IOP measurements. GS had IOPs ranging from 19 to 24 mmHg and/or suspicious appearance of the optic nerve. POAG patients had reproducible abnormal visual fields. We only included patients who presented with short-term IOP fluctuation >6 mm Hg (∆IOP). Only one eye per patient was included through a randomized process. Peripapillary RNFLT was assessed by spectral-domain optical coherence tomography. We correlated RNFLT with IOP parameters. Results: Mean IOP was similar between GS and POAG groups (15.6 ± 3.47 vs 15.6 ± 2.83 mmHg, p = 0.90) as was IOP peak at 6 AM (21.7 ± 3.85 vs 21.3 ± 3.80 mmHg, p = 0.68). Statistically significant negative correlations were found in POAG group between IOP at 6 AM and RNFLT in global ( rs = −0.543; p s = −0.540; p s = −0.405; p = 0.009), and nasal quadrants ( rs = −0.561; p s = −0.591; p s = −0.307; p = 0.047). Conclusion: IOP at 6 AM and ∆IOP had negative correlations with RNFLT quadrants in POAG. In GS this correlation occurred between IOP at 6 AM and inferior quadrant. These findings may indicate potential risk factors for glaucoma progression. |
| Databáze: | OpenAIRE |
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