Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium
| Autor: | Chu Chen, Maria Paula Curado, Zuo-Feng Zhang, Julien Berthiller, Alexander W. Daudt, Hal Morgenstern, Kurt Straif, Morgan A. Marks, Anil K. Chaturvedi, Michael D. McClean, Elaine M. Smith, Paul Brennan, Stephen M. Schwartz, Karl T. Kelsey, Gypsyamber D'Souza, Qingyi Wei, Erich M. Sturgis, Marshall Posner, Victor Wünsch-Filho, Mia Hashibe, Yuan Chin Amy Lee, Elena Matos, Andrew F. Olshan, Leticia Fernandez, Philip Lazarus, Paolo Boffetta, Thomas L. Vaughan, Ana M. B. Menezes, Annah Wyss, Joshua E. Muscat, Sergio Koifman |
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| Přispěvatelé: | Marks, M.A., Chaturvedi, A.K., Kelsey, K., Straif, K., Berthiller, J., Schwartz, S.M., Smith, E., Wyss, A., Brennan, P., Olshan, A.F., Wei, Q., Sturgis, E.M., Zhang, Z.-F., Morgenstern, H., Muscat, J., Lazarus, P., McClean, M., Chen, C., Vaughan, T.L., Wunsch-Filho, V., Curado, M.P., Koifman, S., Matos, E., Menezes, A., Daudt, A.W., Fernandez, L., Posner, M., Boffetta, P., Amy Lee, Y.-C., Hashibe, M., D'Souza, G. |
| Rok vydání: | 2014 |
| Předmět: |
Male
Epidemiology Medical and Health Sciences tobacco Substance Misuse Tobacco Use Risk Factors 2.1 Biological and endogenous factors 2.2 Factors relating to the physical environment Aetiology Tobacco Use Epidemiology Cancer alcohol Incidence Incidence (epidemiology) Confounding HPV infection Middle Aged Tongue Neoplasms Oropharyngeal Neoplasms medicine.anatomical_structure Oncology Head and Neck Neoplasms Carcinoma Squamous Cell Female Adult medicine.medical_specialty Alcohol Drinking Marijuana Smoking Article Tongue Internal medicine Tobacco Oropharyngeal oral tongue cancer medicine Humans Dental/Oral and Craniofacial Disease Aged Tobacco Smoke and Health Squamous Cell Carcinoma of Head and Neck business.industry Prevention Carcinoma Case-control study medicine.disease United States Confidence interval Surgery Good Health and Well Being Latin America Squamous Cell Case-Control Studies Digestive Diseases business marijuana |
| Zdroj: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol 23, iss 1 |
| ISSN: | 1538-7755 1055-9965 |
| Popis: | Background: The incidence of oropharyngeal and oral tongue cancers has increased over the last 20 years which parallels increased use of marijuana among individuals born after 1950. Methods: A pooled analysis was conducted comprising individual-level data from nine case–control studies from the United States and Latin America in the INHANCE consortium. Self-reported information on marijuana smoking, demographic, and behavioral factors was obtained from 1,921 oropharyngeal cases, 356 oral tongue cases, and 7,639 controls. Results: Compared with never marijuana smokers, ever marijuana smokers had an elevated risk of oropharyngeal [adjusted OR (aOR), 1.24; 95% confidence interval (CI): 1.06–1.47] and a reduced risk of oral tongue cancer (aOR, 0.47; 95% CI, 0.29, 0.75). The risk of oropharyngeal cancer remained elevated among never tobacco and alcohol users. The risk of oral tongue cancer was reduced among never users of tobacco and alcohol. Sensitivity analysis adjusting for potential confounding by HPV exposure attenuated the association of marijuana use with oropharyngeal cancer (aOR, 0.99; 95% CI, 0.71–1.25), but had no effect on the oral tongue cancer association. Conclusions: These results suggest that the association of marijuana use with head and neck carcinoma may differ by tumor site. Impact: The associations of marijuana use with oropharyngeal and oral tongue cancer are consistent with both possible pro- and anticarcinogenic effects of cannabinoids. Additional work is needed to rule out various sources of bias, including residual confounding by HPV infection and misclassification of marijuana exposure. Cancer Epidemiol Biomarkers Prev; 23(1); 160–71. ©2013 AACR. |
| Databáze: | OpenAIRE |
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