A soy‐derived antiapoptotic fraction decreases methotrexate toxicity in the gastrointestinal tract of the rat
| Autor: | L D Tomei, Martha Funk‐Archuleta, Hennebold Kl, I C Bathurst, M W Foehr |
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| Rok vydání: | 1997 |
| Předmět: |
Diarrhea
Male Antimetabolites Antineoplastic Cancer Research medicine.medical_specialty Programmed cell death Time Factors media_common.quotation_subject Administration Oral Medicine (miscellaneous) Apoptosis Biology Rats Sprague-Dawley Eating Weight loss Internal medicine Casein medicine Animals Nucleic Acid Synthesis Inhibitors media_common Gastrointestinal tract Nutrition and Dietetics Dose-Response Relationship Drug Incidence Body Weight Appetite Rats Methotrexate Endocrinology Oncology Toxicity Soybean Proteins Folic Acid Antagonists Biological Assay medicine.symptom medicine.drug |
| Zdroj: | Nutrition and Cancer. 29:217-221 |
| ISSN: | 1532-7914 0163-5581 |
| DOI: | 10.1080/01635589709514627 |
| Popis: | The ability of a soy-derived antiapoptotic fraction to inhibit methotrexate-induced gastrointestinal toxicity was examined. Male Sprague-Dawley rats treated with methotrexate were fed diets containing casein as a sole protein source or diets supplemented with a protein-phospholipid fraction isolated from soy flour. This soy fraction has also been shown to inhibit serum deprivation-induced programmed cell death (apoptosis) in the mouse embryonic C3H10T1/2 cell. Rats that received high doses of the soy-derived antiapoptotic fraction-supplemented diets experienced significantly less weight loss and diarrhea and better maintained their pretreatment appetite. |
| Databáze: | OpenAIRE |
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