Respiratory effects of low versus high tidal volume with or without positive end-expiratory pressure in anesthetized dogs with healthy lungs
| Autor: | Fabienne Ferrulli, Valentina De Monte, Francesco Staffieri, Luca Lacitignola, Alberto Maria Crovace, Salvatore Grasso, Antonello Bufalari |
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| Rok vydání: | 2018 |
| Předmět: |
Time Factors
Respiratory rate 040301 veterinary sciences medicine.medical_treatment Mammary Neoplasms Animal gas exchange lung mechanics Pulmonary compliance Tidal volume PEEP lung aeration gas exchange lung mechanics dog 0403 veterinary science Positive-Pressure Respiration 03 medical and health sciences 0302 clinical medicine Dogs Respiratory Rate Tidal Volume Medicine Animals Respiratory function Anesthesia Lung PEEP aeration Positive end-expiratory pressure Tidal volume Anesthetics Mechanical ventilation General Veterinary business.industry Pulmonary Gas Exchange 030208 emergency & critical care medicine 04 agricultural and veterinary sciences General Medicine Oxygenation respiratory system respiratory tract diseases dog Breathing Respiratory Mechanics Female Radiography Thoracic business Tomography X-Ray Computed therapeutics circulatory and respiratory physiology |
| Zdroj: | ResearcherID |
| ISSN: | 1943-5681 |
| Popis: | OBJECTIVE To evaluate the impact of 2 tidal volumes (TVs) with or without positive end-expiratory pressure (PEEP) on lung mechanics, aeration, and gas exchange in healthy anesthetized dogs. ANIMALS 40 mixed-breed dogs with healthy lungs. PROCEDURES Anesthetized dogs were randomly assigned to 4 groups (n = 10/group) with different ventilatory settings: TV of 8 mL/kg and PEEP of 0 cm H2O (low TV group), TV of 8 mL/kg and PEEP of 5 cm H2O (low TV plus PEEP group), TV of 15 mL/kg and PEEP of 0 cm H2O (high TV group), or TV of 15 mL/kg and PEEP of 5 cm H2O (high TV plus PEEP group). Expired CO2 and respiratory rate were titrated on the basis of a predetermined stepwise protocol. Gas exchange, respiratory mechanics, and pulmonary aeration were evaluated by means of CT 30 minutes after starting mechanical ventilation at the assigned setting. RESULTS Partial pressures of arterial and expired CO2 were higher in the low TV and low TV plus PEEP groups than in the high TV and high TV plus PEEP groups. Peak and plateau airway pressures were higher in the PEEP group than in the other groups. Static lung compliance was higher in the high TV plus PEEP group than in the low TV group. Relative percentages of atelectatic and poorly aerated lung were lower in the high TV plus PEEP group than in the other groups. Oxygenation was similar among groups. CONCLUSIONS AND CLINICAL RELEVANCE Differences in TV and PEEP application during mechanical ventilation may affect respiratory function in anesthetized dogs with healthy lungs. Ventilation with a TV of 15 mL/kg and PEEP of 5 cm H2O significantly improved lung compliance and reduced the amount of atelectatic and poorly aerated lung. |
| Databáze: | OpenAIRE |
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