Evaluation of the reproductive performance of women with elevated day 10 progesterone levels during ovarian reserve screening
| Autor: | Glen E. Hofmann, Gary M. Horowitz, Daniel Navot, Jennifer Thie, Richard T. Scott |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Menotropins Time Factors media_common.quotation_subject Fertility Clomiphene Andrology Pregnancy Follicular phase Humans Prospective Studies Ovarian reserve Menstrual Cycle Progesterone Menstrual cycle media_common Estradiol biology Reproduction Incidence (epidemiology) Ovary Ovarian hyperstimulation Obstetrics and Gynecology Luteinizing Hormone Fecundity Follicular Phase Reproductive Medicine HMG-CoA reductase biology.protein Female Follicle Stimulating Hormone |
| Zdroj: | Fertility and Sterility. 63:979-983 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)57533-5 |
| Popis: | Objectives To evaluate the relationship of elevated day 10 P levels (≥1.1ng/mL, conversion factor to SI unit, 3.18) during ovarian reserve screening and reproductive performance. Design Prospective screening with longitudinal follow-up. Interventions One hundred seven women underwent ovarian reserve screening with a clomiphene citrate challenge test. Main Outcome Measures Serum FSH, LH, and E 2 levels were determined on cycle day 3 and FSH, LH, and P levels were determined on day 10. A fertility evaluation was completed and a treatment plan was instituted. Results : Twenty-two of 107 (20.6%) women had day 10 P levels ≥1.1ng/mL. Women with elevated day 10 P levels were similar in age to women with normal day 10 P levels (≤0.9ng/mL) but had significantly shorter menstrual cycles, higher day 3 and day 10 FSH levels, higher day 3 E 2 levels, and higher day 10 LH levels than women with normal day 10 P levels. During ovarian hyperstimulation, women with elevated day 10 P levels required more ampules of hMG, had lower peak E 2 levels, and had fewer mature follicles than women with a normal day 10 P level. Sixteen of 85 (18.8%) women with normal day 10 P levels became pregnant, but none of the 22 women with elevated day 10 P levels became pregnant. The incidence of diminished ovarian reserve was higher in women with elevated day 10 P levels (13/22; 59%) when compared with women with a normal day 10 P levels (9/85; 10.6%). Conclusions : Elevated day 10 P levels (≥1.1ng/mL) during ovarian reserve screening is associated with diminished ovarian reserve and correlates with menstrual cycle parameters associated with a short follicular phase and poor reproductive performance. |
| Databáze: | OpenAIRE |
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