| Autor: |
Andreas Nowacki, David Zhang, Jonathan Wermelinger, Pablo Abel Alvarez Abut, Jan Rosner, Claudio Pollo, Kathleen Seidel |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Nowacki, Andreas; Zhang, David; Wermelinger, Jonathan; Alvarez Abut, Pablo Abel; Rosner, Jan; Pollo, Claudio; Seidel, Kathleen (2023). Directional recordings of somatosensory evoked potentials from the sensory thalamus in chronic poststroke pain patients. Clinical neurophysiology, 151, pp. 50-58. Elsevier 10.1016/j.clinph.2023.03.359 |
| DOI: |
10.1016/j.clinph.2023.03.359 |
| Popis: |
OBJECTIVE The aim of this feasibility study was to investigate the properties of median nerve somatosensory evoked potential (SEPs) recorded from segmented Deep Brain Stimulation (DBS) leads in the sensory thalamus (VP) and how they relate to clinical and anatomical findings. METHODS We analyzed four patients with central post-stroke pain and DBS electrodes placed in the VP. Median nerve SEPs were recorded with referential and bipolar montages. Electrode positions were correlated with thalamus anatomy and tractography-based medial lemniscus. Early postoperative clinical paresthesia mapping was performed by an independent pain nurse. Finally, we performed frequency and time-frequency analyses of the signals. RESULTS We observed differences of SEP amplitudes recorded along different directions in the VP. SEP amplitudes did not clearly correlate to both atlas-based anatomical position and fiber-tracking results of the medial lemniscus. However, the contacts of highest SEP amplitude correlated with the contacts of lowest effect-threshold to induce paraesthesia. CONCLUSIONS SEP recordings from directional DBS leads offer additional information about the neurophysiological (re)organization of the sensory thalamus. SIGNIFICANCE Directional recordings of thalamic SEPs bear the potential to assist clinical decision-making in DBS for pain. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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