The long noncoding RNA LINC00312 induces lung adenocarcinoma migration and vasculogenic mimicry through directly binding YBX1

Autor:	Dan He, Bin Shan, Zhenzi Peng, Yeping Dong, Chunfang Zhang, Yuanda Cheng, Wenwen Shi, Minghao Duan, Bin Li, Wei Peng, Chaojun Duan, Wenyuan Zhao, Jun Wang
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	0301 basic medicine Lung adenocarcinoma Cancer Research Lung Neoplasms Adenocarcinoma of Lung Biology lcsh:RC254-282 Metastasis Neovascularization YBX1 03 medical and health sciences 0302 clinical medicine Cell Movement Cell Line Tumor LINC00312 medicine Humans Vasculogenic mimicry Lung cancer Letter to the Editor Transcription factor Cell Proliferation Neovascularization Pathologic Binding protein Cell Differentiation respiratory system medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Long non-coding RNA 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research Molecular Medicine Adenocarcinoma RNA Long Noncoding Y-Box-Binding Protein 1 medicine.symptom
Zdroj:	Molecular Cancer, Vol 17, Iss 1, Pp 1-6 (2018) Molecular Cancer
ISSN:	1476-4598
DOI:	10.1186/s12943-018-0920-z
Popis:	Vasculogenic mimicry (VM) gives rise to tumor neovascularization that is critical for tumor growth and metastasis. Long non-coding RNAs (lncRNAs) have been implicated in diverse and fundamental biological processes. LINC00312 is associated with lung adenocarcinoma. In this study, we found that LINC00312 induced migration, invasion and VM of lung cancer cells by direct binding to the transcription factor Y-Box Binding Protein 1 (YBX1). Moreover, we demonstrated that YBX1 is associated with different fragments within 0–2410 nt 5’region of LINC00312. In addition, LINC00312 is associated with VM in 124 lung adenocarcinoma clinical specimens. The results suggest that LINC00312 is a promising therapeutic and diagnostic target for lung adenocarcinoma. Electronic supplementary material The online version of this article (10.1186/s12943-018-0920-z) contains supplementary material, which is available to authorized users.
Databáze:	OpenAIRE
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