Carbon dioxide inhalation, stress and anxiogenic drugs reduce the function of GABAA receptor complex in the rat brain
Autor: | A, Concas, E, Sanna, T, Cuccheddu, M P, Mascia, G, Santoro, E, Maciocco, G, Biggio |
---|---|
Rok vydání: | 1993 |
Předmět: |
Male
Receptor complex medicine.drug_class Anxiety Pharmacology FG-7142 Hippocampus Anxiolytic Ion Channels Rats Sprague-Dawley Benzodiazepines Bridged Bicyclo Compounds chemistry.chemical_compound Chloride Channels Cerebellum Administration Inhalation medicine Animals Biological Psychiatry Brain Chemistry Cerebral Cortex Electroshock Inhalation Chemistry GABAA receptor Membrane Proteins Carbon Dioxide Bridged Bicyclo Compounds Heterocyclic Receptors GABA-A Abecarnil Rats Anti-Anxiety Agents Alprazolam Anxiogenic Stress Psychological Carbolines medicine.drug |
Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 17:651-661 |
ISSN: | 0278-5846 |
DOI: | 10.1016/0278-5846(93)90012-h |
Popis: | 1. The effect of different stressful stimuli on the function of the GABAA-ionophore receptor complex was evaluated by measuring the binding of 35S-TBPS to the chloride channel associated recognition sites. 2. Foot-shock stress enhanced 35S-TBPS binding in membrane preparation from rat cerebral cortex. The effect of foot-shock on 35S-TBPS binding was mimicked by the anxiogenic and proconvulsant beta-carboline FG 7142 and antagonized by anxiolytic benzodiazepines and by the novel anxiolytic and anticonvulsant beta-carboline, abecarnil. 3. A brief exposure of rats to CO2 inhalation produced, like foot-shock and FG 7142, a marked increase of 35S-TBPS binding in the cerebral cortex, cerebellum and hippocampus. The effect of CO2 inhalation was maximal 10 min after treatment and return to control value in 2 hours. Previous administration of anxiolytic drugs (alprazolam and abecarnil) completely prevented the CO2 inhalation-induced increase of 35S-TBPS binding. 4. All together these data strongly suggest that carbon dioxide inhalation, like stress and anxiogenic drugs, decreases the function of the GABAA receptor complex. |
Databáze: | OpenAIRE |
Externí odkaz: |