Detrimental effects of a bout of physical exercise on circulating endogenous inhibitors of endothelial function in patients with coronary artery disease
| Autor: | Stevan Ilic, Gordana Lazarevic, Giuseppe Ambrosio, Gordana Kocic, Marina Deljanin Ilic, Radmila Pavlovic, Tatjana Cvetkovic, Slavoljub Zivanovic |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Physical exercise Coronary Artery Disease 030204 cardiovascular system & hematology Arginine Asymptomatic Nitric oxide Coronary artery disease 03 medical and health sciences Basal (phylogenetics) chemistry.chemical_compound Young Adult 0302 clinical medicine Risk Factors Internal medicine medicine Humans Risk factor Exercise Aged biology business.industry General Medicine Middle Aged medicine.disease Nitric oxide synthase 030104 developmental biology Endocrinology chemistry Echocardiography Case-Control Studies biology.protein Cardiology Exercise Test Female medicine.symptom Nitric Oxide Synthase Asymmetric dimethylarginine business Cardiology and Cardiovascular Medicine Biomarkers |
| Zdroj: | Journal of cardiovascular medicine (Hagerstown, Md.). 18(8) |
| ISSN: | 1558-2035 |
| Popis: | A bout of intense physical activity has been shown to transiently impair endothelial function; however, the underlying mechanisms are unclear. The purpose of the review was to assess the impact of a bout of physical exercise induced by exercise stress echocardiography, on blood concentration of the endogenous inhibitors of nitric oxide synthase, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA), in patients with atherosclerosis. Overall, 83 study participants were enrolled, 25 coronary artery disease (CAD) patients, 20 age and sex-matched asymptomatic study participants with at least one risk factor for CAD, and 38 healthy controls. Patients with CAD developed symptoms and/or left ventricular wall motion abnormalities during exercise; no changes were seen in study participants with risk factors, or in healthy controls. At baseline, in CAD patients and in study participants with risk factors, both ADMA and SDMA were higher than healthy controls (P |
| Databáze: | OpenAIRE |
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