Are pulmonary hemostasis and fibrinolysis out of balance in equine chronic pneumopathies?
| Autor: | Ann Kristin Barton, Heidrun Gehlen, Ralf Einspanier, Caroline Wirth, Angelika Bondzio |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Lung Diseases medicine.medical_specialty 040301 veterinary sciences medicine.medical_treatment Fibrinogen Gastroenterology 0403 veterinary science Fibrin Fibrinogen Degradation Products 03 medical and health sciences recurrent airway obstruction Internal medicine Fibrinolysis medicine Animals Serum amyloid A Horses Respiratory system Recurrent airway obstruction inflammatory airway disease Hemostasis Serum Amyloid A Protein General Veterinary medicine.diagnostic_test business.industry chronic interstitial pneumopathy inflammatory biomarker 04 agricultural and veterinary sciences medicine.disease Airway Obstruction 030104 developmental biology Bronchoalveolar lavage Coagulation Original Article Horse Diseases business Bronchoalveolar Lavage Fluid medicine.drug Acute-Phase Proteins |
| Zdroj: | Journal of Veterinary Science |
| ISSN: | 1976-555X 1229-845X |
| Popis: | Clinical examination, bronchoalveolar lavage fluid (BALF) cytology, acute- phase protein, and pulmonary hemostasis and fibrinolysis marker (fibrinogen, serum amyloid A [SAA], and D-dimer) results were compared between control and respiratory disease-affected horses. Using a clinical scoring system, horses (n = 58) were classified as respiratory disease-free (Controls, n = 15) or with recurrent airway obstruction (RAO; n = 18), inflammatory airway disease (n = 14) or chronic interstitial pneumopathy (n = 11). There were no significant differences in fibrinogen concentrations among groups, but there was a trend toward a lower value in controls (median 0.0024 g/L) than in horses with chronic pneumopathies (median 0.0052 g/L), in particular, those with RAO (median 0.0062 g/L). Fibrinogen concentration was positively correlated with percentage of neutrophils in BALF (rs = 0.377, p = 0.004). SAA concentrations were low; 65.5% of samples were below the detection limit. D-dimer concentrations were also low and quantifiable concentrations were only obtained after ultrafiltration and only in RAO (median 0.1 mg/L). In conclusion, there was limited evidence of increased coagulatory activity in chronic pneumopathies, apart from RAO. It is uncertain whether fibrinogen and D-dimer concentrations increased due to their role as acute-phase proteins or as a misbalance of coagulation and fibrinolysis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|