c-myc gene activation as a permanent trait of RSV-infected quail cells
| Autor: | R. Friis, I. Hlozánek, Helena Fidlerová, Vlasta Sovová |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Gene Expression Regulation
Viral Sarcoma Avian Transcriptional Activation Cancer Research Mutant Genes myc Coturnix Biology Sensitivity and Specificity Virus Gene product Proto-Oncogene Proteins c-myc biology.animal Gene expression Animals Permissive Rous sarcoma virus Temperature Embryo biology.organism_classification Cell Transformation Viral Virology Molecular biology Quail Gene Expression Regulation Neoplastic Phenotype Oncology Avian Sarcoma Viruses |
| Zdroj: | International journal of cancer. 53(6) |
| ISSN: | 0020-7136 |
| Popis: | A high level of c-myc gene expression was found to be a constant feature of v-src transformation. The c-myc gene product was analyzed in quail embryo cells transformed by different mutants of Rous sarcoma virus (RSV) that were temperature-sensitive with respect to various parameters of v-src function. The high-level expression of c-myc proved not to be temperature-sensitive: at both permissive (35 degrees C) and non-permissive (41 degrees C) temperatures, the same high levels of c-myc gene product were found for all RSV mutants tested. This result, in agreement with earlier evidence for a v-src-induced proliferative stimulus which was unaffected by ts mutants at the non-permissive temperature, shows that certain v-src functions have not yet been fully characterized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text