C-type natriuretic peptide is associated with the severity of Crimean-Congo hemorrhagic fever
| Autor: | Ali Zorlu, Aynur Engin, Muhammed Mirhan Polat, Kenan Ahmet Turkdogan, Mehmet Yilmaz, Fatma Mutlu Kukul Güven, Okan Onur Turgut |
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| Přispěvatelé: | [Zorlu, Ali] Bulanik State Hosp, Dept Cardiol, Mus, Turkey -- [Turkdogan, Kenan Ahmet -- Guven, Fatma Mutlu Kukul] Isparta State Hosp, Dept Emergency, Isparta, Turkey -- [Engin, Aynur] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Turgut, Okan Onur -- Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Sch Med, Dept Cardiol, Sivas, Turkey, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, Turgut, Okan -- 0000-0002-6847-3029, kukul guven, fatma mutlu -- 0000-0003-3755-6021 |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Microbiology (medical) Crimean–Congo hemorrhagic fever medicine.medical_specialty medicine.drug_class Severity of Illness Index Gastroenterology Sepsis chemistry.chemical_compound Internal medicine Lactate dehydrogenase medicine Natriuretic peptide Humans Risk stratification Aged Univariate analysis business.industry Septic shock Confounding Natriuretic Peptide C-Type General Medicine Odds ratio Middle Aged Prognosis medicine.disease Surgery Infectious Diseases ROC Curve chemistry Crimean-Congo hemorrhagic fever Female Hemorrhagic Fever Crimean business C-type natriuretic peptide |
| Zdroj: | International Journal of Infectious Diseases. 16:e616-e620 |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2012.04.009 |
| Popis: | WOS: 000307124100007 PubMed ID: 22695238 Background: Crimean-Congo hemorrhagic fever (CCHF) is characterized by vascular dysfunction, indicating the involvement of endothelial cells. C-type natriuretic peptide (CNP) plays a critical role in the coordination of vascular tone and is associated with the prognosis in critically ill patients such as those with sepsis and septic shock. We investigated whether CNP is related to the severity of CCHF. Methods: Forty-eight consecutive patients with a laboratory confirmed diagnosis of CCHF and 40 age-sex-matched healthy volunteers as the control group were prospectively enrolled into the study. CCHF patients were classified according to the disease severity into a non-severe group (n = 28) and a severe group (n = 20). Results: The CNP levels were detected to be 0.43 (0.4-0.7) ng/ml in the control group, 0.87 (0.7-1.0) ng/ml in the non-severe CCFH group, and 1.27 (0.8-1.7) ng/ml in the severe CCHF group. According to the receiver operating characteristics curve analysis, the optimal cut-off value of CNP to predict disease severity was >1.22 ng/ml, with 89.3% specificity and 55% sensitivity. CNP >1.22 ng/ml, lactate dehydrogenase >480 IU/l, and aspartate aminotransferase >202 IU/l were found to have prognostic significance in the univariate analysis. In the multivariate logistic regression analysis by forward stepwise method, CNP >1.22 ng/ml (odds ratio 8.336, p = 0.016) and lactate dehydrogenase > 480 IU/l (odds ratio 16.206, p = 0.002) remained associated with disease severity after adjustment for confounding variables. Conclusions: CNP measurement could help in the risk stratification of patients with CCHF. (C) 2012 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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