A Stereocontrolled Synthesis of δ-trans-Tocotrienoloic Acid

Autor:	Sidney M. Hecht, David J. Maloney
Rok vydání:	2005
Předmět:	Alkylation Molecular Structure Chemistry Stereochemistry Organic Chemistry Total synthesis Stereoisomerism Iodides Biochemistry Tocotrienoloic acid Cyclization Vitamin E Stereoselectivity Desiccation Physical and Theoretical Chemistry Polymerase β Hydrogen
Zdroj:	Organic Letters. 7:4297-4300
ISSN:	1523-7052 1523-7060
Popis:	[reaction: see text] A concise stereoselective total synthesis of a naturally occurring polymerase beta inhibitor, delta-trans-tocotrienoloic acid (2), is described. The key step in the synthesis is an acid-catalyzed cyclodehydration reaction. Additionally, this report corrects a previously reported structural assignment, defines the absolute stereochemistry of 2, and defines key structural requirements for polymerase beta inhibition.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0fb949c9e81238bff8341cf864b9eb https://doi.org/10.1021/ol051849t Zobrazit plný text záznamu