A Stereocontrolled Synthesis of δ-trans-Tocotrienoloic Acid
Autor: | Sidney M. Hecht, David J. Maloney |
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Rok vydání: | 2005 |
Předmět: | |
Zdroj: | Organic Letters. 7:4297-4300 |
ISSN: | 1523-7052 1523-7060 |
Popis: | [reaction: see text] A concise stereoselective total synthesis of a naturally occurring polymerase beta inhibitor, delta-trans-tocotrienoloic acid (2), is described. The key step in the synthesis is an acid-catalyzed cyclodehydration reaction. Additionally, this report corrects a previously reported structural assignment, defines the absolute stereochemistry of 2, and defines key structural requirements for polymerase beta inhibition. |
Databáze: | OpenAIRE |
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