Follow-up of Mild Hypothyroidism in a Nursing Home
| Autor: | Elizabeth Langer, Wolfram E. Nolten, Paul J. Drinka, Susan K. Voeks |
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| Rok vydání: | 1991 |
| Předmět: |
Male
endocrine system medicine.medical_specialty endocrine system diseases Normal free thyroxine Thyrotropin Gastroenterology Wisconsin Hypothyroidism Internal medicine Homes for the Aged Humans Mass Screening Medicine Aged Aged 80 and over business.industry Mean age Middle Aged medicine.disease Anti-thyroid autoantibodies Myasthenia gravis Nursing Homes Thyroxine Endocrinology Hypothyroxinemia Thyroid autoimmunity Female Geriatrics and Gerontology business Nursing homes hormones hormone substitutes and hormone antagonists Clinical progression Follow-Up Studies |
| Zdroj: | Journal of the American Geriatrics Society. 39:264-266 |
| ISSN: | 0002-8614 |
| Popis: | The course of untreated mild hypothyroidism was followed in 67 nursing home residents (mean age 78 years). The diagnosis was based on a normal free thyroxine index (FTI) and elevated thyrotropin concentration (TSH 4.6 to 15.0 microIU/mL, nl less than or equal to 4.5 microIU/mL. FTI and FSH were measured in follow-up 42-378 (mean 161) days after the diagnosis of mild hypothyroidism had been made. In 45 patients initial TSH was less than 6.8 microIU/mL; in 23 of these subjects TSH returned to normal during the observation period, whereas in 22 TSH remained elevated. In all 22 residents whose initial TSH was greater than 6.8 microIU/mL, TSH remained elevated at follow-up. In 4 subjects whose initial TSH concentrations ranged from 5.0 to 9.6 microIU/mL, FTI fell below normal 91-141 days after the diagnosis of mild hypothyroidism was made. Clinical progression of the signs or symptoms of hypothyroidism was not detected in the 4 patients who developed hypothyroxinemia. Three demonstrated positive thyroid antibody titers, and 1 had myasthenia gravis. These observations suggest a need for replacement therapy in debilitated patients with mild hypothyroidism and evidence of thyroid autoimmunity. |
| Databáze: | OpenAIRE |
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