Memory disruption in rats with nigral lesions induced by MPTP: a model for early Parkinson's disease amnesia
| Autor: | Edmar Miyoshi, Maria A.B.F. Vital, Reinaldo N. Takahashi, Da Cunha C, Roberto Andreatini, Monique S. Gevaerd, Newton S. Canteras, Silveira R |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Parkinson's disease Dopamine Conditioning Classical Nigrostriatal pathway Amnesia Substantia nigra Avoidance response Behavioral Neuroscience chemistry.chemical_compound Parkinsonian Disorders Basal ganglia Neural Pathways medicine Avoidance Learning Animals Rats Wistar MPTP Association Learning Retention Psychology medicine.disease Rats Substantia Nigra medicine.anatomical_structure nervous system chemistry 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine Mental Recall medicine.symptom Psychology Neuroscience medicine.drug |
| Zdroj: | Behavioural brain research. 124(1) |
| ISSN: | 0166-4328 |
| Popis: | Intra-nigral administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) caused a lesion in the substantia nigra, compact part (SNc) and a specific loss of dopamine and its metabolites in the striatum of rats. The animals were then tested in the two-way active avoidance task. MPTP-treated animals presented lower learning scores in the training and test sessions, an effect that was not caused by motor impairment or by a decreased sensitivity to footshock since their reaction time to the footshock (unconditioned stimulus - UCS) was not reduced. These lower scores were also not attributable to lower acoustic sensitivity or to a slowing in the association of the sound cue (conditioned stimulus - CS) with the UCS since the reaction time to the CS in the active avoidance response did not differ between MPTP-treated and control groups. Therefore, these results are more properly attributable to an impairment of the memory acquisition and retention processes. In addition, this study is presented as a model of early Parkinson's Disease amnesia and is discussed in terms of the importance of the nigrostriatal pathway to memory acquisition and storage processes. |
| Databáze: | OpenAIRE |
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