A universal biosensing platform based on optical micro-ring resonators
| Autor: | Shaopeng Wang, S.J. Ja, John V. Hryniewicz, Akhilesh Ramachandran, Sai T. Chu, D. Gill, Brent E. Little, E.M. Flood, Lawrence L. Wald, E. Knobbe, John Clarke, O. King, W. Chen, David W. Goad |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Optics and Photonics
Silicon Spectrophotometry Infrared Biomedical Engineering Biophysics chemistry.chemical_element Biosensing Techniques Ring (chemistry) Sensitivity and Specificity law.invention Photometry Resonator Optical reader Data acquisition Optics law Electrochemistry business.industry High-refractive-index polymer Reproducibility of Results General Medicine Equipment Design Equipment Failure Analysis Refractometry chemistry Optical cavity Optoelectronics business Biosensor Biotechnology |
| Zdroj: | Biosensorsbioelectronics. 23(7) |
| ISSN: | 0956-5663 |
| Popis: | The use of optical micro-ring resonators as a platform for quantitative and qualitative biosensing applications was explored. Vertically coupled, high refractive index micro-ring resonators, used as sensing elements, were fabricated on silicon chips by photolithographic techniques. An optical reader system consisting of a near-infrared broad band light source and an optical spectrum analyzer were employed for data acquisition. Micro-ring resonator surfaces were modified with specific target receptors, including antibodies and single-stranded DNA oligonucleotides. The system was successfully used for label-free, specific, and rapid detection of whole bacterial cells, proteins and nucleic acids. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect